ReviewMechanisms of ageing and development2019
Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics.
Review in Mechanisms of ageing and development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed.
- Repurposing Pimozide as a Geroprotector: Lifespan Extension via SKN-1 Activation and Collagen Remodeling inAntioxidants (Basel, Switzerland) · 2026Article
- 3,5-Dicaffeoylquinic Acid Delayed Aging and Promoted Oxidative Stress Tolerance via Activation of the SKN-1/Nrf2 Signaling Pathway.Food science & nutrition · 2026Article
- Multilayered regulation of longevity in Caenorhabditis elegans.Molecules and cells · 2026Review
- Aging impairs the antiviral defense in Caenorhabditis elegans due to loss of DRH-1/RIG-I deSUMOylation by ULP-4/SENP7.EMBO reports · 2025Article
- Herbal Cuscutae Semen Contributes to Oxidative Stress Tolerance and Extends Lifespan via Sirtuin1 inAntioxidants (Basel, Switzerland) · 2025Article
- The C. elegans glutamate transporters GLT-4 and GLT-5 regulate protein expression, behavior, and lifespan.Neurochemistry international · 2025Article
- The ISN Neuroscience School, Ondo 2024, Gene-environment interactions in neurological disorders: a contemporary update.Biology open · 2025Article
- Molecular mechanism of culinary herb Artemisia argyi in promoting lifespan and stress tolerance.NPJ science of food · 2024Article
- Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age.GeroScience · 2024Article
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- Combinatorial transcriptomic and genetic dissection of insulin/IGF-1 signaling-regulated longevity in Caenorhabditis elegans.Aging cell · 2024Article
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- Article
- Effects of insecticidal proteins ofFrontiers in microbiology · 2023Article
- Chromatin: the old and young of it.Frontiers in molecular biosciences · 2023Review
- Dietary cobalt oxide nanoparticles alleviate aging through activation of mitochondrial UPR inTheranostics · 2023Article
- Curcumin supplementation increases longevity and antioxidant capacity inFrontiers in pharmacology · 2023Article
- Role of autophagy in lung diseases and ageing.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Further Extension of Lifespan byCells · 2022Article
- Molecular Mechanisms for Anti-aging of Low-Vacuum Cold Plasma Pretreatment in Caenorhabditis elegans.Applied biochemistry and biotechnology · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Key discoveries in aging research have been made possible with the use of model organisms. Caenorhabditis elegans is a short-lived nematode that has become a well-established system to study aging. The practicality and powerful genetic manipulations associated with this metazoan have revolutionized our ability to understand how organisms age. 25 years after the publication of the discovery of the daf-2 gene as a genetic modifier of lifespan, C. elegans remains as relevant as ever in the quest to understand the process of aging. Nematode aging research has proven useful in identifying transcriptional regulators, small molecule signals, cellular mechanisms, epigenetic modifications associated with stress resistance and longevity, and lifespan-extending compounds. Here, we review recent discoveries and selected topics that have emerged in aging research using this incredible little worm.
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