Evidence map›Paper›PMID 30133930›Full record

ArticleAddiction (Abingdon, England)2019

A transdiagnostic dimensional approach towards a neuropsychological assessment for addiction: an international Delphi consensus study.

Murat Yücel, Erin Oldenhof, Serge H Ahmed, David Belin, Joel Billieux, Henrietta Bowden-Jones, Adrian Carter, Samuel R Chamberlain, Luke Clark, Jason Connor and 31 more

Abstract readConsensus Statement
In one paragraph

Article in Addiction (Abingdon, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Cognitive Inflexibility in OCD and Related Disorders.Current topics in behavioral neurosciences · 2021
    Pooled it
  6. Impulsivity in Gambling Disorder and problem gambling: a meta-analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
    Pooled it
  7. Pooled it
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  9. Does alcohol cue inhibitory control training survive a context shift?Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020
    Trial
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  11. Article
  12. Risk calculation circuit abnormalities plus psychosocial risk variables predict problematic substance use in youth with externalizing disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  16. Review
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  18. D2 autoreceptors gate vulnerability to cocaine use disorder.bioRxiv : the preprint server for biology · 2026
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  19. Article
  20. The Paradoxical Effect of Cannabis Use on Cognition in Chronic Psychotic Disorders.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Article

57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

41 authors.

Murat YücelBrain and Mental Health Research Hub, Monash Institute of Cognitive and Clinical Neurosciences (MICCN) and School of Psychological Sciences, Monash University, Melbourne, Australia.ORCID 0000-0002-4705-452X
Erin OldenhofBrain and Mental Health Research Hub, Monash Institute of Cognitive and Clinical Neurosciences (MICCN) and School of Psychological Sciences, Monash University, Melbourne, Australia.
Serge H AhmedInstitut des Maladies Neurodégénératives, Université de Bordeaux, Bordeaux, France.ORCID 0000-0002-1225-9234
David BelinDepartment of Psychology, University of Cambridge, Cambridge, UK.
Joel BillieuxAddictive and Compulsive Behaviours Laboratory (ACB-lab), Institute for Health and Behaviours, University of Luxembourg, Esch-sur-Alzette, Luxembourg.ORCID 0000-0002-7388-6194
Henrietta Bowden-JonesDepartment of Medicine, Imperial College, London, UK.
Adrian CarterBrain and Mental Health Research Hub, Monash Institute of Cognitive and Clinical Neurosciences (MICCN) and School of Psychological Sciences, Monash University, Melbourne, Australia.ORCID 0000-0002-3593-0772
Samuel R ChamberlainDepartment of Psychiatry, University of Cambridge; and Cambridge and Peterborough NHS Foundation Trust (CPFT), Cambridge, UK.
Luke ClarkCentre for Gambling Research at UBC, Department of Psychology, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0003-1103-2422
Jason ConnorDiscipline of Psychiatry, Faculty of Medicine, and Centre for Youth Substance Abuse Research, The University of Queensland, Brisbane, Australia.
Mark DaglishAlcohol and Drug Service, Royal Brisbane and Women's Hospital, Metro North HHS, Queensland Health and Discipline of Psychiatry, The University of Queensland, Australia.ORCID 0000-0002-1787-4375
Geert DomAntwerp University (UA), Collaborative Antwerp Psychiatric Research Institute (CAPRI), Antwerp, Belgium.
Pinhas DannonDepartment of Psychiatry, the Sackler School of Medicine and Tel Aviv University, Tel Aviv, Israel.
Theodora DukaSussex Addiction Research and Intervention Centre, School of Psychology, University of Sussex, Brighton, UK.
Maria Jose Fernandez-SerranoDepartamento de Psicología, Universidad de Jaén, Spain.
Matt FieldDepartment of Psychology, University of Sheffield, Sheffield, UK.
Ingmar FrankenInstitute of Psychology, Erasmus School of Social Sciences and Behavioral Sciences, Erasmus University, Rotterdam, the Netherlands.
Rita Z GoldsteinDepartment of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, NY, USA.
Raul GonzalezCenter for Children and Families, Department of Psychology, Florida International University, Miami, FL.
Anna E GoudriaanArkin Mental Health and Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Institute for Addiction Research, Amsterdam, Netherlands.ORCID 0000-0001-8670-9384
Jon E GrantDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-7784-7021
Matthew J GulloCentre for Youth Substance Abuse Research, The University of Queensland, Brisbane, Australia.ORCID 0000-0003-3657-5191
Robert HesterSchool of Psychological Sciences, University of Melbourne, Melbourne, Australia.ORCID 0000-0003-0982-8026
David C HodginsDepartment of Psychology, University of Calgary, Calgary, Canada.ORCID 0000-0003-2737-5200
Bernard Le FollTranslational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Canada.ORCID 0000-0002-6406-4973
Rico S C LeeBrain and Mental Health Research Hub, Monash Institute of Cognitive and Clinical Neurosciences (MICCN) and School of Psychological Sciences, Monash University, Melbourne, Australia.
Anne Lingford-HughesNeuropsychopharmacology Unit, Centre for Psychiatry, Division of Brain Sciences, Imperial College, London, UK.ORCID 0000-0003-4512-3453
Valentina LorenzettiSchool of Psychology, Faculty of Health Sciences, Australian Catholic University, Melbourne, Australia.
Scott J MoellerDepartment of Psychiatry, Stony Brook University School of Medicine, Stony Brook, NY, USA.ORCID 0000-0002-4449-0844
Marcus R MunafòMRC Integrative Epidemiology Unit at the University of Bristol and UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, University of Bristol, Bristol, UK.ORCID 0000-0002-4049-993X
Brian OdlaugFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-5407-0686
Marc N PotenzaDepartments of Psychiatry and Neuroscience, Child Study Center, Yale University School of Medicine and Connecticut Mental Health Center and Connecticut Council on Problem Gambling, New Haven, CT, USA.
Rebecca SegraveBrain and Mental Health Research Hub, Monash Institute of Cognitive and Clinical Neurosciences (MICCN) and School of Psychological Sciences, Monash University, Melbourne, Australia.
Zsuzsika SjoerdsDepartment of Neurology, Max-Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.ORCID 0000-0001-9467-3772
Nadia SolowijSchool of Psychology and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia.ORCID 0000-0002-5222-5637
Wim van den BrinkAmsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Institute for Addiction Research, Amsterdam, Netherlands.
Ruth J van HolstAmsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Institute for Addiction Research, Amsterdam, Netherlands.
Valerie VoonDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Reinout WiersAddiction, Development and Psychopathology (ADAPT)-lab, Deptartment of Psychology, University of Amsterdam, the Netherlands.ORCID 0000-0002-4312-9766
Leonardo F FontenelleBrain and Mental Health Research Hub, Monash Institute of Cognitive and Clinical Neurosciences (MICCN) and School of Psychological Sciences, Monash University, Melbourne, Australia.
Antonio Verdejo-GarciaBrain and Mental Health Research Hub, Monash Institute of Cognitive and Clinical Neurosciences (MICCN) and School of Psychological Sciences, Monash University, Melbourne, Australia.ORCID 0000-0001-8874-9339

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Neuroimaging response inhibition and salience attribution changes during mindfulness-based treatment of human heroin addictionR01AT010627 · NCCIH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GOLDSTEIN, RITA Z · 2019 to 2023
$3.8M
Using event-related potentials to longitudinally track cue-induced craving incubation in cocaine addicted individualsR01DA041528 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GOLDSTEIN, RITA Z · 2016 to 2020
$3.3M
Genetic markers associated with brain structural abnormalities and drug use in human addictionK01DA037452 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI MOELLER, SCOTT J · 2015 to 2019
$778k
Medical Research Council MC_UU_00011/7Medical Research Council MR/K023195/1Medical Research Council MR/N02530X/1Medical Research Council MR/P008747/1NCATS NIH HHS UL1 TR001863NCCIH NIH HHS R01 AT010627NIDA NIH HHS K01 DA037452NIDA NIH HHS R01 DA041528
6 · The paper itself

Abstract

backgroundThe US National Institutes of Mental Health Research Domain Criteria (RDoC) seek to stimulate research into biologically validated neuropsychological dimensions across mental illness symptoms and diagnoses. The RDoC framework comprises 39 functional constructs designed to be revised and refined, with the overall goal of improving diagnostic validity and treatments. This study aimed to reach a consensus among experts in the addiction field on the 'primary' RDoC constructs most relevant to substance and behavioural addictions.

methodsForty-four addiction experts were recruited from Australia, Asia, Europe and the Americas. The Delphi technique was used to determine a consensus as to the degree of importance of each construct in understanding the essential dimensions underpinning addictive behaviours. Expert opinions were canvassed online over three rounds (97% completion rate), with each consecutive round offering feedback for experts to review their opinions.

resultsSeven constructs were endorsed by ≥ 80% of experts as 'primary' to the understanding of addictive behaviour: five from the Positive Valence System (reward valuation, expectancy, action selection, reward learning, habit); one from the Cognitive Control System (response selection/inhibition); and one expert-initiated construct (compulsivity). These constructs were rated to be related differentially to stages of the addiction cycle, with some linked more closely to addiction onset and others more to chronicity. Experts agreed that these neuropsychological dimensions apply across a range of addictions.

conclusionsThe study offers a novel and neuropsychologically informed theoretical framework, as well as a cogent step forward to test transdiagnostic concepts in addiction research, with direct implications for assessment, diagnosis, staging of disorder, and treatment.

Indexed as

AsiaAustraliaBehavior, AddictiveCompulsive BehaviorDecision MakingDelphi TechniqueEuropeHabitsHumansInhibition, PsychologicalLearningNational Institute of Mental Health (U.S.)North AmericaRewardSouth AmericaSubstance-Related DisordersAddictionassessmentcognitioncompulsionsdecision-makinghabitRDoCrewardtransdiagnostic

Identifiers

PMID30133930
PMCPMC6386631

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.