ArticleJournal of veterinary internal medicine2018
Lipid peroxidation biomarkers for evaluating oxidative stress in equine neuroaxonal dystrophy.
Article in Journal of veterinary internal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Untargeted and Targeted Cerebrospinal Fluid Neurometabolomics via Chromatography-Mass Spectrometry-Based Methods.Molecules (Basel, Switzerland) · 2026Review
- Increased α-tocopherol metabolism in horses with equine neuroaxonal dystrophy.Journal of veterinary internal medicine · 2021Article
- The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis.Antioxidants (Basel, Switzerland) · 2021Review
- Metabolic Profiling and Quantitative Analysis of Cerebrospinal Fluid Using Gas Chromatography-Mass Spectrometry: Current Methods and Future Perspectives.Molecules (Basel, Switzerland) · 2021Review
- Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values.Frontiers in molecular biosciences · 2019Review
- Lipid peroxidation biomarkers for evaluating oxidative stress in equine neuroaxonal dystrophy.Journal of veterinary internal medicine · 2018Article
- Equine degenerative myeloencephalopathy: prevalence, impact, and management.Veterinary medicine (Auckland, N.Z.) · 2018Review
- Genetic polymorphisms in vitamin E transport genes as determinants for risk of equine neuroaxonal dystrophy.Journal of veterinary internal medicineArticle
- Measurement of 8-hydroxy-2'-deoxyguanosine in serum and cerebrospinal fluid of horses with neuroaxonal degeneration and other causes of proprioceptive ataxia.Journal of veterinary internal medicineArticle
- Efficacy of the oral supplement, Equine Omega Complete, for the prevention of gastric ulcers and alpha-tocopherol supplementation in horses.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundEquine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (eNAD/EDM) is a neurodegenerative disorder affecting genetically predisposed foals maintained on an α-tocopherol (α-TOH) deficient diet. Currently no antemortem diagnostic test for eNAD/EDM is available. HYPOTHESIS: Because α-TOH deficiency is associated with increased lipid peroxidation, it was hypothesized that F ANIMALS: Isoprostane Study A: 14 Quarter horse foals (10 healthy foals and 4 eNAD/EDM affected foals) at 1 and 6 months of age. Isoprostane Study B: 17 eNAD/EDM affected and 10 unaffected horses ≥ 1-4 years of age. Oxysterol study: eNAD/EDM affected (n = 14, serum; n = 11, CSF; n = 10, spinal cord [SC]) and unaffected horses 1-4 years of age (n = 12, serum; n = 10, CSF; n = 7, SC). PROCEDURES: Cerebrospinal fluid [F
resultsSpinal cord [7-ketocholesterol], [7-hydroxycholesterol], and [7-keto-27-hydrocholesterol] were higher in eNAD/EDM horses whereas [24-ketocholesterol] was lower. No significant difference was found in CSF [F CONCLUSIONS AND CLINICAL IMPORTANCE: In the SC, targeted markers of cholesterol oxidation were significantly increased in horses with eNAD/EDM.
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