Evidence map›Paper›PMID 30133719›Full record

ArticlePacing and clinical electrophysiology : PACE2018

Correlation between atrial fibrillation driver locations and complex fractionated atrial electrograms in patients with persistent atrial fibrillation.

Sonia Ammar-Busch, Tilko Reents, Sebastien Knecht, Thomas Rostock, Thomas Arentz, Mattias Duytschaever, Thomas Neumann, Bruno Cauchemez, Jean-Paul Albenque, Gabriele Hessling and 1 more

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Article in Pacing and clinical electrophysiology : PACE, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
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  6. Article
  7. Integrating mapping methods for atrial fibrillation.Pacing and clinical electrophysiology : PACE · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Sonia Ammar-BuschKlinikum Coburg, Coburg, Germany.ORCID 0000-0003-0123-7213
Tilko ReentsDepartment of Electrophysiology, Deutsches Herzzentrum München, Technische Universitaet, Munich, Germany.
Sebastien KnechtAZ Sint-Jan, Bruges, Belgium.
Thomas RostockJohannes Gutenberg-University Mainz, University Hospital, II. Medical Clinic, Germany.
Thomas ArentzUniversitäts-Herzzentrum Freiburg-Bad Krozingen, Bad Krozingen, Germany.
Mattias DuytschaeverAZ Sint-Jan, Bruges, Belgium.
Thomas NeumannKerckhoff Heart Center, Bad Nauheim, Germany.
Bruno CauchemezClinique Ambroise Paré, Neuilly-sur-Seine, France.
Jean-Paul AlbenqueClinique Pasteur, Toulouse, France.
Gabriele HesslingDepartment of Electrophysiology, Deutsches Herzzentrum München, Technische Universitaet, Munich, Germany.
Isabel DeisenhoferDepartment of Electrophysiology, Deutsches Herzzentrum München, Technische Universitaet, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of this study was to evaluate a spatial correlation between active atrial fibrillation (AF) drivers measured by electrocardiographic imaging and complex fractionated atrial electrograms (CFAEs) in patients with persistent AF.

methodsSixteen patients with persistent AF were included. A biatrial geometry relative to an array of 252-body-surface-electrodes was obtained from a noncontrast computed tomography scan. The reconstructed unipolar AF electrograms were signal-processed (ECVUE™, CardioInsight Technologies Inc., Cleveland, OH, USA) to identify AF drivers. Before driver ablation, a biatrial mapping using the NavX system (St. Jude Medical, St. Paul, MN, USA) was performed to identify CFAEs. CFAE and driver regions were then quantified and compared.

resultsAF was terminated by driver ablation in 11/16 (70%) patients. The mean number of ablated driver regions was 4 ± 1 per patient. The most frequent driver locations were the inferior left atrium and coronary sinus, the right pulmonary veins, and the right atrium. In 49/63 (78%) of the driver locations, more than 75% of the driver site showed CFAEs. The mean ablated driver area was 58 ± 24 cm

conclusionsThere is a significant overlap between AF driver regions identified by the ECVUE™ system and CFAE areas identified by the NavX system. AF driver regions are smaller and mostly embedded in larger CFAE areas. Selective ablation of drivers in CFAE areas seems sufficient to terminate persistent AF in the majority of patients.

Indexed as

Tomography, X-Ray ComputedAgedAtrial FibrillationBody Surface Potential MappingCatheter AblationElectrocardiographyFemaleHumansMaleMiddle AgedSignal Processing, Computer-AssistedTreatment Outcomeatrial fibrillationelectrogram analysismappingrotorsthree-dimensional systems

Identifiers

PMID30133719

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.