ArticlePloS one2018
The interaction between N-terminal pro-brain natriuretic peptide and fluid status in adverse clinical outcomes of late stages of chronic kidney disease.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bioimpedance Indices of Fluid Overload and Cardiorenal Outcomes in Heart Failure and Chronic Kidney Disease: a Systematic Review.Journal of cardiac failure · 2022Pooled it
- Empagliflozin and fluid balance: results from the SiRENA project.Clinical kidney journal · 2025Article
- Left Ventricular Geometry and Inferior Vena Cava Diameter Co-Modify the Risk of Cardiovascular Outcomes in Chronic Hemodialysis Patients.Medicina (Kaunas, Lithuania) · 2024Article
- The association of plasma NT-proBNP level and progression of diabetic kidney disease.Renal failure · 2023Article
- Associations between N-Terminal Pro-B-Type Natriuretic Peptide, Body Fluid Imbalance and Quality of Life in Patients Undergoing Hemodialysis: A Cross-Sectional Study.Journal of clinical medicine · 2023Article
- Association between Intra- and Extra-Cellular Water Ratio Imbalance and Natriuretic Peptides in Patients Undergoing Hemodialysis.Nutrients · 2023Article
- Impact of socioeconomic and cardiovascular risk factors on the effect of genetic variants associated with NT-proBNP.Scientific reports · 2022Article
- HFA-PEFF score: prognosis in patients with preserved ejection fraction after transcatheter aortic valve implantation.ESC heart failure · 2022Article
- Chronic Kidney Disease and Heart Failure-Everyday Diagnostic Challenges.Diagnostics (Basel, Switzerland) · 2021Review
- Association of N-Terminal Pro-brain Natriuretic Peptide With Volume Status and Cardiac Function in Hemodialysis Patients.Frontiers in cardiovascular medicine · 2021Article
- Low Intracellular Water, Overhydration, and Mortality in Hemodialysis Patients.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFluid overload is one of the major characteristics and complications in patients with chronic kidney disease (CKD). N-terminal pro-brain natriuretic peptide (NT-proBNP) is related to fluid status and fluid distribution. The aim of this study is to investigate the interaction between NT-proBNP and fluid status in adverse clinical outcomes of late stages of CKD.
methodsWe enrolled 239 patients with CKD stages 4-5 from January 2011 to December 2011 and followed up until June 2017. Fluid status was presented as hydration status (HS) value measured by body composition monitor, while HS>7% was defined as fluid overload. Clinical outcomes included renal outcomes (commencing dialysis and estimated glomerular filtration rate decline>3 ml/min/1.73 m2/year), all-cause mortality and major adverse cardiovascular events (MACEs).
resultsDuring a mean follow-up of 3.3±2.0 years, 129(54.7%) patients commenced dialysis, 88(37.3%) patients presented rapid renal function decline, and 48(20.3%) had MACEs or died. All patients were stratified by HS of 7% and the median of plasma NT-proBNP. The adjusted risks for commencing dialysis was significantly higher in patients with high plasma NT-proBNP and HS>7% compared to those with low plasma NT-proBNP and HS≦7%. There was a significant interaction between plasma NT-proBNP and HS in commencing dialysis (P-interaction = 0.047). Besides, patients with high plasma NT-proBNP and HS>7% had greater risks for MACEs or all-cause mortality than others with either high plasma NT-proBNP or HS>7%.
conclusionNT-proBNP and fluid overload might have a synergistic association of adverse clinical outcomes in patients with late stages of CKD.
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