Evidence map›Paper›PMID 30133303›Full record

ReviewAmerican journal of physiology. Regulatory, integrative and comparative physiology2018

Influence of dietary protein on Dahl salt-sensitive hypertension: a potential role for gut microbiota.

Justine M Abais-Battad, David L Mattson

Open access · bronzeAbstract readReview
In one paragraph

Review in American journal of physiology. Regulatory, integrative and comparative physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Justine M Abais-BattadDepartment of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.
David L MattsonDepartment of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.
Medical College of Wisconsin · US

Funding

Therapeutic Effects of mTOR Inhibition in Salt-Sensitive HypertensionP01HL116264 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI STARUSCHENKO, ALEXANDER · 2013 to 2021
$18.7M
Role of CD247 in Salt-Sensitive Hypertension and Renal DiseaseR01DK096859 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI MATTSON, DAVID L. · 2012 to 2016
$1.7M
NADPH oxidase-mediated NLRP3 Inflammasome Activation in Dahl Salt-Sensitive HypertensionF32HL136161 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI ABAIS-BATTAD, JUSTINE M · 2017 to 2017
$51k
NHLBI NIH HHS F32 HL136161NHLBI NIH HHS P01 HL116264NIDDK NIH HHS R01 DK096859
6 · The paper itself

Abstract

High blood pressure affects 1.39 billion adults across the globe and is the leading preventable cause of death worldwide. Hypertension is a multifaceted disease with known genetic and environmental factors contributing to its progression. Our studies utilizing the Dahl salt-sensitive (SS) rat have demonstrated the remarkable influence of dietary protein and maternal environment on the development of hypertension and renal damage in response to high salt. There is growing interest in the relationship between the microbiome and hypertension, with gut dysbiosis being correlated to a number of pathologies. This review summarizes the current literature regarding the interplay among dietary protein, the gut microbiota, and hypertension. These studies may provide insight into the effects we have observed between diet and hypertension in Dahl SS rats and, we hope, lead to new perspectives where potential dietary interventions or microbiota manipulations could serve as plausible therapies for hypertension.

Indexed as

AnimalsBlood PressureDietary ProteinsGastrointestinal MicrobiomeHumansHypertensionKidneySodium Chloride, DietaryDietary ProteinsSodium Chloride, Dietaryblood pressuredietary interventionsmicrobiome

Identifiers

PMID30133303
PMCPMC6295491
OpenAlexW2888067795

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.