Evidence map›Paper›PMID 30133114›Full record

ArticleJournal of cellular and molecular medicine2018

Influence of lifestyle choices on risks of CYP1B1 polymorphisms for prostate cancer.

Taku Kato, Yutaka Hashimoto, Ryan K Wong, Yozo Mitsui, Shigekatsu Maekawa, Inik Chang, Varahram Shahryari, Soichiro Yamamura, Shahana Majid, Sharanjot Saini and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Taku KatoDepartment of Urology, Veterans Affairs Medical Center, San Francisco, CA, USA.
Yutaka HashimotoDepartment of Urology, Veterans Affairs Medical Center, San Francisco, CA, USA.
Ryan K WongDepartment of Urology, Veterans Affairs Medical Center, San Francisco, CA, USA.
Yozo MitsuiDepartment of Urology, Veterans Affairs Medical Center, San Francisco, CA, USA.
Shigekatsu MaekawaDepartment of Urology, Veterans Affairs Medical Center, San Francisco, CA, USA.
Inik ChangDepartment of Oral Biology, Yonsei University College of Dentistry, Seoul, South Korea.
Varahram ShahryariDepartment of Urology, Veterans Affairs Medical Center, San Francisco, CA, USA.
Soichiro YamamuraDepartment of Urology, Veterans Affairs Medical Center, San Francisco, CA, USA.
Shahana MajidDepartment of Urology, Veterans Affairs Medical Center, San Francisco, CA, USA.
Sharanjot SainiDepartment of Urology, Veterans Affairs Medical Center, San Francisco, CA, USA.
Z Laura TabatabaiDepartment of Pathology, Veterans Affairs Medical Center and University of California, San Francisco, CA, USA.
Rajvir DahiyaDepartment of Urology, Veterans Affairs Medical Center, San Francisco, CA, USA.
Takashi DeguchiDepartment of Urology, Gifu University Graduate school of Medicine, Gifu, Japan.
Yuichiro TanakaDepartment of Urology, Veterans Affairs Medical Center, San Francisco, CA, USA.ORCID 0000-0002-4849-4981
San Francisco VA Medical Center · USGifu University · JPYonsei University · KR

Funding

Racial differences in CYP1B1 polymorphisms and risks for prostate cancerR21CA185003 · NCI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI TANAKA, YUICHIRO · 2015 to 2016
$367k
BLRD VA I01 BX000726NCI NIH HHS R21 CA185003
6 · The paper itself

Abstract

Cytochrome P450 1B1 (CYP1B1) converts xenobiotics to carcinogens and how lifestyle choices may interact with CYP1B1 polymorphisms and affect prostate cancer risk was assessed. Blood genomic DNA from a Caucasian population was analysed at polymorphic sites of the 5' untranslated region of CYP1B1 using TaqMan genotyping assays. Overall, drinker status and minor alleles at rs2551188, rs2567206 and rs10175368 were associated with prostate cancer. Linkage was observed between rs2551188, rs2567206, rs2567207 and rs10175368, and the G-C-T-G haplotype (major allele at respective sites) was decreased in cancer. Interestingly when classified by lifestyle factors, no associations of genotypes were found for non-smokers and non-drinkers, whereas on the contrary, minor type at rs2567206 and rs10175368 increased and major G-C-T-G decreased risk for cancer among smokers and drinkers. Interestingly, rs2551188, rs2567206 and rs10175368 minor genotypes correlated with increased tissue CYP1B1 as determined by immunohistochemistry. Further, rs10175368 enhanced luciferase activity and mobility shift show stronger binding of nuclear factor for the minor allele. These results demonstrate smoking and alcohol consumption to modify the risks of CYP1B1 polymorphisms for prostate cancer which may be through rs10175368, and this is of importance in understanding their role in the pathogenesis and as a biomarker for this disease.

Indexed as

Gene-Environment InteractionPolymorphism, GeneticAdultAgedAged, 80 and overAlcohol DrinkingAllelesCase-Control StudiesCell Line, TumorCytochrome P-450 CYP1B1Gene ExpressionHaplotypesHumansLife StyleMaleMiddle AgedCYP1B1 protein, humanCytochrome P-450 CYP1B1alcohol consumptioncytochrome P450 1B1polymorphismsprostate cancersmoker

Identifiers

PMID30133114
PMCPMC6156244
OpenAlexW2888593288

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.