ArticleHuman brain mapping2018
The system-neurophysiological basis for how methylphenidate modulates perceptual-attentional conflicts during auditory processing.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Pharmacological modulation of directed network communication and neural hubs in action-effect integration.The international journal of neuropsychopharmacology · 2025Trial
- Neurobiological influences on event perception: the role of catecholamines.The international journal of neuropsychopharmacology · 2025Trial
- The Ability to Voluntarily Regulate Theta Band Activity Affects How Pharmacological Manipulation of the Catecholaminergic System Impacts Cognitive Control.The international journal of neuropsychopharmacology · 2024Trial
- Auricular Transcutaneous Vagus Nerve Stimulation Diminishes Alpha-Band-Related Inhibitory Gating Processes During Conflict Monitoring in Frontal Cortices.The international journal of neuropsychopharmacology · 2022Trial
- Perception-Action Integration Is Modulated by the Catecholaminergic System Depending on Learning Experience.The international journal of neuropsychopharmacology · 2021Trial
- Learning Experience Reverses Catecholaminergic Effects on Adaptive Behavior.The international journal of neuropsychopharmacology · 2020Trial
- Neurophysiological insights into catecholamine-dependent tDCS modulation of cognitive control.Communications biology · 2025Article
- Effects of Catecholaminergic and Transcranial Direct Current Stimulation on Response Inhibition.The international journal of neuropsychopharmacology · 2024Article
- Electroencephalography source localization.Clinical and experimental pediatrics · 2023Article
- Unsigned surprise but not reward magnitude modulates the integration of motor elements during actions.Scientific reports · 2023Article
- Resting-state theta activity is linked to information content-specific coding levels during response inhibition.Scientific reports · 2022Article
- The Downsides of Cognitive Enhancement.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2021Article
- Neurophysiological and functional neuroanatomical coding of statistical and deterministic rule information during sequence learning.Human brain mapping · 2021Article
- A novel approach to intra-individual performance variability in ADHD.European child & adolescent psychiatry · 2021Article
- Anodal tDCS modulates specific processing codes during conflict monitoring associated with superior and middle frontal cortices.Brain structure & function · 2021Article
- Cognitive profile in Restless Legs Syndrome: A signal-to-noise ratio account.Current research in neurobiology · 2021Review
- Decoding Stimulus-Response Representations and Their Stability Using EEG-Based Multivariate Pattern Analysis.Cerebral cortex communications · 2020Article
- The Presynaptic Regulation of Dopamine and Norepinephrine Synthesis Has Dissociable Effects on Different Kinds of Cognitive Conflicts.Molecular neurobiology · 2019Article
- On the relevance of EEG resting theta activity for the neurophysiological dynamics underlying motor inhibitory control.Human brain mapping · 2019Article
- How the depth of processing modulates emotional interference - evidence from EEG and pupil diameter data.Cognitive, affective & behavioral neuroscience · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to selectively perceive and flexibly attend to relevant sensory signals in the environment is essential for action control. Whereas neuromodulation of sensory or attentional processing is often investigated, neuromodulation of interactive effects between perception and attention, that is, high attentional control demand when the relevant sensory information is perceptually less salient than the irrelevant one, is not well understood. To fill this gap, this pharmacological-electroencephalogram (EEG) study applied an intensity-modulated, focused-attention dichotic listening paradigm together with temporal EEG signal decomposition and source localization analyses. We used a double-blind MPH/placebo crossover design to delineate the effects of methylphenidate (MPH)-a dopamine/norepinephrine transporter blocker-on the resolution of perceptual-attentional conflicts, when perceptual saliency and attentional focus favor opposing ears, in healthy young adults. We show that MPH increased behavioral performance specifically in the condition with the most pronounced conflict between perceptual saliency and attentional focus. On the neurophysiological level, MPH effects in line with the behavioral data were observed after accounting for intraindividual variability in the signal. More specifically, MPH did not show an effect on stimulus-related processes but modulated the onset latency of processes between stimulus evaluation and responding. These modulations were further shown to be associated with activation differences in the temporoparietal junction (BA40) and the superior parietal cortex (BA7) and may reflect neuronal gain modulation principles. The findings provide mechanistic insights into the role of modulated dopamine/norepinephrine transmitter systems for the interactions between perception and attention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.