Evidence map›Paper›PMID 30132986›Full record

ArticleClinical transplantation2018

Association of the kidney allocation system with dialysis exposure before deceased donor kidney transplantation by preemptive wait-listing status.

Meera N Harhay, Michael O Harhay, Karthik Ranganna, Suzanne M Boyle, Lissa Levin Mizrahi, Stephen Guy, Gregory E Malat, Gary Xiao, David J Reich, Rachel E Patzer

Open access · greenAbstract read
In one paragraph

Article in Clinical transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. An overview of frailty in kidney transplantation: measurement, management and future considerations.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Meera N HarhayDivision of Nephrology and Hypertension, Department of Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania.ORCID 0000-0001-6500-2814
Michael O HarhayDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Karthik RangannaDivision of Nephrology and Hypertension, Department of Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Suzanne M BoyleDivision of Nephrology and Hypertension, Department of Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Lissa Levin MizrahiDivision of Nephrology and Hypertension, Department of Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Stephen GuyDivision of Multi-Organ Transplantation and Hepatobiliary Surgery, Department of Surgery, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Gregory E MalatDivision of Multi-Organ Transplantation and Hepatobiliary Surgery, Department of Surgery, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Gary XiaoDivision of Multi-Organ Transplantation and Hepatobiliary Surgery, Department of Surgery, Drexel University College of Medicine, Philadelphia, Pennsylvania.
David J ReichDivision of Multi-Organ Transplantation and Hepatobiliary Surgery, Department of Surgery, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Rachel E PatzerDivision of Transplantation, Department of Surgery, Emory University School of Medicine, Atlanta, Georgia.
Drexel University · USEmory University · US

Funding

Patterns and Implications of Functional Decline Among Kidney Transplant CandidatesK23DK105207 · NIDDK · DREXEL UNIVERSITY · PI HARHAY, MEERA NAIR · 2015 to 2019
$861k
Improving the measurement and analysis of long-term, patient-centered outcomes following acute respiratory failureK99HL141678 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI HARHAY, MICHAEL OSCAR · 2018 to 2019
$214k
NHLBI NIH HHS K99 HL141678NIDDK NIH HHS K23 DK105207
6 · The paper itself

Abstract

backgroundIt is unknown whether the new kidney transplant allocation system (KAS) has attenuated the advantages of preemptive wait-listing as a strategy to minimize pretransplant dialysis exposure.

methodsWe performed a retrospective study of adult US deceased donor kidney transplant (DDKT) recipients between December 4, 2011-December 3, 2014 (pre-KAS) and December 4, 2014-December 3, 2017 (post-KAS). We estimated pretransplant dialysis durations by preemptive listing status in the pre- and post-KAS periods using multivariable gamma regression models.

resultsAmong 65 385 DDKT recipients, preemptively listed recipients (21%, n = 13 696) were more likely to be white (59% vs 34%, P < 0.001) and have private insurance (64% vs 30%, P < 0.001). In the pre- and post-KAS periods, average adjusted pretransplant dialysis durations for preemptively listed recipients were <2 years in all racial groups. Compared to recipients who were listed after starting dialysis, preemptively listed recipients experienced 3.85 (95% Confidence Interval [CI] 3.71-3.99) and 4.53 (95% CI 4.32-4.74) fewer average years of pretransplant dialysis in the pre- and post-KAS periods, respectively (P < 0.001 for all comparisons).

conclusionsPreemptively wait-listed DDKT recipients continue to experience substantially fewer years of pretransplant dialysis than recipients listed after dialysis onset. Efforts are needed to improve both socioeconomic and racial disparities in preemptive wait-listing.

Indexed as

Kidney TransplantationResource AllocationWaiting ListsAdultAgedCadaverFemaleFollow-Up StudiesHumansKidney Failure, ChronicMaleMiddle AgedPrognosisRenal DialysisRetrospective StudiesRisk Factorskidney transplantwaiting list

Identifiers

PMID30132986
PMCPMC6191313
OpenAlexW2888057427

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.