ArticleLab on a chip2018
Quantitative phase microscopy of red blood cells during planar trapping and propulsion.
Article in Lab on a chip, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Spatial microfluidic holographic integrated platform for label-free and high-dimensional analysis of cancer heterogeneity.Nature communications · 2025Article
- Advances in Microfluidics for Single Red Blood Cell Analysis.Biosensors · 2023Review
- Demystifying speckle field interference microscopy.Scientific reports · 2022Article
- Raman and quantitative phase imaging allow morpho-molecular recognition of malignancy and stages of B-cell acute lymphoblastic leukemia.Biosensors & bioelectronics · 2021Article
- High-throughput spatial sensitive quantitative phase microscopy using low spatial and high temporal coherent illumination.Scientific reports · 2021Article
- Characterization of Liposomes Using Quantitative Phase Microscopy (QPM).Pharmaceutics · 2021Article
- Highly temporal stable, wavelength-independent, and scalable field-of-view common-path quantitative phase microscope.Journal of biomedical optics · 2020Article
- Towards biological applications of nanophotonic tweezers.Current opinion in chemical biology · 2019Review
- Optical elastography and tissue biomechanics.Journal of biomedical optics · 2019Article
- Peculiarities of control of erythrocytes moving in an evanescent field.Journal of biomedical optics · 2019Article
- Partially spatially coherent digital holographic microscopy and machine learning for quantitative analysis of human spermatozoa under oxidative stress condition.Scientific reports · 2019Article
- Reagent-Free and Rapid Assessment of T Cell Activation State Using Diffraction Phase Microscopy and Deep Learning.Analytical chemistry · 2019Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 4 countries.
Funding
Abstract
Red blood cells (RBCs) have the ability to undergo morphological deformations during microcirculation, such as changes in surface area, volume and sphericity. Optical waveguide trapping is suitable for trapping, propelling and deforming large cell populations along the length of the waveguide. Bright field microscopy employed with waveguide trapping does not provide quantitative information about structural changes. Here, we have combined quantitative phase microscopy and waveguide trapping techniques to study changes in RBC morphology during planar trapping and transportation. By using interference microscopy, time-lapsed interferometric images of trapped RBCs were recorded in real-time and subsequently utilized to reconstruct optical phase maps. Quantification of the phase differences before and after trapping enabled study of the mechanical effects during planar trapping. During planar trapping, a decrease in the maximum phase values, an increase in the surface area and a decrease in the volume and sphericity of RBCs were observed. QPM was used to analyze the phase values for two specific regions within RBCs: the annular rim and the central donut. The phase value of the annular rim decreases whereas it increases for the central donut during planar trapping. These changes correspond to a redistribution of cytosol inside the RBC during planar trapping and transportation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.