Evidence map›Paper›PMID 30132384›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019

Modulator of apoptosis-1 is a potential therapeutic target in acute ischemic injury.

Su Jing Chan, Hui Zhao, Kazuhide Hayakawa, Chou Chai, Chong Teik Tan, Jiawen Huang, Ran Tao, Gen Hamanaka, Thiruma V Arumugam, Eng H Lo and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. EphrinB2-EphB2 signaling for dendrite protection after neuronal ischemiaJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Su Jing ChanDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore.
Hui ZhaoDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore.
Kazuhide HayakawaDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Chou ChaiNeurodegeneration Laboratory, Research Department, National Neuroscience Institute, Singapore, Singapore.
Chong Teik TanDepartment of Pharmacy, National University of Singapore, Singapore, Singapore.
Jiawen HuangDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore.
Ran TaoDepartment of Pharmacy, National University of Singapore, Singapore, Singapore.
Gen HamanakaDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Thiruma V ArumugamDepartment of Physiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore.
Eng H LoDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Victor Chun Kong YuDepartment of Pharmacy, National University of Singapore, Singapore, Singapore.
PeterTsun-Hon WongDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore.
National University Health System · SGMassachusetts General Hospital · USNational University of Singapore · SGHarvard University · USNational Neuroscience Institute · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modulator of apoptosis 1 (MOAP-1) is a Bax-associating protein highly enriched in the brain. In this study, we examined the role of MOAP-1 in promoting ischemic injuries following a stroke by investigating the consequences of MOAP-1 overexpression or deficiency in in vitro and in vivo models of ischemic stroke. MOAP-1 overexpressing SH-SY5Y cells showed significantly lower cell viability following oxygen and glucose deprivation (OGD) treatment when compared to control cells. Consistently, MOAP-1

Indexed as

ApoptosisAcute DiseaseAdaptor Proteins, Signal TransducingAnimalsApoptosis Regulatory ProteinsBrain IschemiaCell HypoxiaCerebral CortexDisease Models, AnimalMiceMice, KnockoutNeuronsAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsMoap1 protein, mouseAcute ischemic injuryBax-associating proteinin vitro and in vivo stroke modelsmodulator of apoptosis 1therapeutic target

Identifiers

PMID30132384
PMCPMC6893981
OpenAlexW2888402321

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.