ArticleAmerican journal of physiology. Renal physiology2018
Electrical stimulation of the pudendal nerve promotes neuroregeneration and functional recovery from stress urinary incontinence in a rat model.
Article in American journal of physiology. Renal physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Investigating the Mechanism of Conditioning Versus Postoperative Electrical Stimulation to Enhance Nerve Regeneration: One Therapy, Two Distinct Effects.Muscle & nerve · 2025Pooled it
- Evidence evaluation of acupuncture and its related therapies for female urinary incontinence: an overview and quality assessment of systematic reviews and meta-analyses.European journal of physical and rehabilitation medicine · 2024Pooled it
- Molecular Processes in Stress Urinary Incontinence: A Systematic Review of Human and Animal Studies.International journal of molecular sciences · 2022Pooled it
- Omental pedicle transposition for neuropathic stress urinary incontinence: a urodynamic evaluation.Open veterinary journal · 2026Article
- Cellular regenerative therapy in stress urinary incontinence: new frontiers?-a narrative review.Translational andrology and urology · 2024Review
- Basic mechanisms of peripheral nerve injury and treatment via electrical stimulation.Neural regeneration research · 2022Review
- Effect of electroacupuncture on the intestinal microflora in rats with stress urinary incontinence.Frontiers in endocrinology · 2022Article
- Brain-Derived Neurotrophic Factor Is an Important Therapeutic Factor in Mesenchymal Stem Cell Secretions for Treatment of Traumatic Peripheral Pelvic Injuries.Frontiers in cellular neuroscience · 2022Article
- Time course for urethral neuromuscular reestablishment and its facilitated recovery by transcutaneous neuromodulation after simulated birth trauma in rats.Scientific reports · 2021Article
- Effects of an alpha-1d adrenoreceptor antagonist (naftopidil) on bladder dysfunction after radiotherapy in female rats.International urogynecology journal · 2021Article
- Stable softening bioelectronics: A paradigm for chronically viable ester-free neural interfaces such as spinal cord stimulation implants.Biomaterials · 2021Article
- Regenerative medicine for anal incontinence: a review of regenerative therapies beyond cells.International urogynecology journal · 2021Review
- Diagnosis and Treatment of Obstetric Anal Sphincter Injuries: New Evidence and Perspectives.Journal of clinical medicine · 2021Review
- Targeted neuromodulation of pelvic floor nerves in aging and multiparous rabbits improves continence.Scientific reports · 2021Article
- Medications used to treat bladder disorders may alter effects of neuromodulation.Neurourology and urodynamics · 2020Article
- [Application and progress of neuromodulation in lower urinary tract dysfunction].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Review
- Combined Treatment With CCR1-Overexpressing Mesenchymal Stem Cells and CCL7 Enhances Engraftment and Promotes the Recovery of Simulated Birth Injury-Induced Stress Urinary Incontinence in Rats.Frontiers in surgery · 2020Article
- Daily bilateral pudendal nerve electrical stimulation improves recovery from stress urinary incontinence.Interface focus · 2019Article
- Electrical stimulation for neuroregeneration in urology: a new therapeutic paradigm.Current opinion in urology · 2019Review
- Electrical stimulation enhances neuronal cell activity mediated by Schwann cell derived exosomes.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
The pudendal nerve can be injured during vaginal delivery of children, and slowed pudendal nerve regeneration has been correlated with development of stress urinary incontinence (SUI). Simultaneous injury to the pudendal nerve and its target muscle, the external urethral sphincter (EUS), during delivery likely leads to slowed neuroregeneration. The goal of this study was to determine if repeat electrical stimulation of the pudendal nerve improves SUI recovery and promotes neuroregeneration in a dual muscle and nerve injury rat model of SUI. Rats received electrical stimulation or sham stimulation of the pudendal nerve twice weekly for up to 2 wk after injury. A separate cohort of rats received sham injury and sham stimulation. Expression of brain-derived neurotrophic factor (BDNF) and β
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.