Evidence map›Paper›PMID 30132293›Full record

Trial reportJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2019

CFTR IVS8 Poly-T Variation Affects Severity of Acute Pancreatitis in Women.

Ivan Radosavljevic, Bojan Stojanovic, Marko Spasic, Slobodan Jankovic, Natasa Djordjevic

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ivan RadosavljevicFaculty of Medical Sciences, Department of Surgery, University of Kragujevac, Svetozara Markovica 69, Kragujevac, 34 000, Serbia.
Bojan StojanovicFaculty of Medical Sciences, Department of Surgery, University of Kragujevac, Svetozara Markovica 69, Kragujevac, 34 000, Serbia.
Marko SpasicFaculty of Medical Sciences, Department of Surgery, University of Kragujevac, Svetozara Markovica 69, Kragujevac, 34 000, Serbia.
Slobodan JankovicFaculty of Medical Sciences, Department of Pharmacology and toxicology, University of Kragujevac, Svetozara Markovica 69, Kragujevac, 34 000, Serbia.
Natasa DjordjevicFaculty of Medical Sciences, Department of Pharmacology and toxicology, University of Kragujevac, Svetozara Markovica 69, Kragujevac, 34 000, Serbia. natashadj2002@yahoo.com.ORCID 0000-0003-4525-6723
University of Kragujevac · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCystic fibrosis transmembrane conductance regulator (CFTR) is important for normal pancreatic function. Its coding gene is polymorphic, and the variations have been associated with the increased risk for acute pancreatitis. However, their impact on the disease severity is still unknown. Therefore, the aim of our study was to determine the functional importance of common cystic fibrosis transmembrane conductance regulator variations IVS8-poly T, R117H, and M470V for the severity of acute pancreatitis.

methodThe study involved 98 acute pancreatitis patients. The severity of the disease was determined based on the Atlanta Classification system. IVS8-poly T, R117H, and M470V genotyping was performed using PCR-RFLP method.

resultsIVS8-5T, IVS8-7T, IVS8-9T, and M470V alleles were found at the frequencies of 5.7, 75.5, 18.9, and 55.7%, respectively, while R117H was not observed. Among women, the severe form of the disease was more frequent in carriers of at least one IVS8 9T allele (RR for 9T/9T + 9T/non-9T vs. non-9T/non-9T: 2.115; 95% CI: 1.241-3.605). This association was not detected in men and was not affected by M470V. In addition, co-morbidities increased the severity of acute pancreatitis (p = 0.022).

conclusionOur study reveals that IVS8 poly-T variation affects severity of acute pancreatitis in women and that existent co-morbidities worsen the clinical course of the disease.

Indexed as

AdultAgedAged, 80 and overComorbidityCystic Fibrosis Transmembrane Conductance RegulatorFemaleHeterozygoteHumansMaleMiddle AgedMutationPancreatitisSeverity of Illness IndexSex FactorsYoung AdultCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorAcute pancreatitisCFTRIVS8-poly TSex

Identifiers

PMID30132293
OpenAlexW2888003772

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.