Evidence map›Paper›PMID 30132184›Full record

ArticleLa Radiologia medica2019

Transcatheter arterial chemoembolization combined with simultaneous DynaCT-guided radiofrequency ablation in the treatment of solitary large hepatocellular carcinoma.

Hongjun Yuan, Fengyong Liu, Xin Li, Yang Guan, Maoqiang Wang

Abstract read
In one paragraph

Article in La Radiologia medica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hongjun YuanDepartment of Interventional Radiology, General Hospital of People's Liberation Army, 28 Fuxing Road, Beijing, 100853, People's Republic of China.
Fengyong LiuDepartment of Interventional Radiology, General Hospital of People's Liberation Army, 28 Fuxing Road, Beijing, 100853, People's Republic of China. liufengyong301@163.com.ORCID http://orcid.org/0000-0002-4474-1308
Xin LiDepartment of Interventional Radiology, General Hospital of People's Liberation Army, 28 Fuxing Road, Beijing, 100853, People's Republic of China.
Yang GuanDepartment of Interventional Radiology, General Hospital of People's Liberation Army, 28 Fuxing Road, Beijing, 100853, People's Republic of China.
Maoqiang WangDepartment of Interventional Radiology, General Hospital of People's Liberation Army, 28 Fuxing Road, Beijing, 100853, People's Republic of China.

Funding

National Natural Science Foundation of China 81671800Natural Science Foundation of Beijing Municipality 7172204
6 · The paper itself

Abstract

purposeTo introduce the technique and investigate the clinical efficacy of transcatheter arterial chemoembolization (TACE) in combination with simultaneous DynaCT-guided radiofrequency ablation (RFA) in the treatment of solitary large hepatocellular carcinomas (HCCs) (maximal diameter > 5 cm). MATERIALS AND

methodsForty-six patients who received TACE combined with simultaneous DynaCT-guided RFA for solitary large HCCs between January 2012 and August 2016 were reviewed, and the success rate, safety, local tumor progression (LTP), and overall survival (OS) were retrospectively investigated. OS and time to progression were analyzed with the Kaplan-Meier method.

resultsTechnical success rate was 100%, average operative time for DynaCT-guided RFA was 45.3 ± 4.8 min, average radiation dose was 730.5 ± 78.8 mGy, and no life-threatening complications were observed. At 1-month follow-up enhanced MRI, complete remission was achieved in 82.6% of patients (38/46), and partial remission in 17.4% (8/46). The median follow-up period was 29.5 months (interquartile range 4.0-69.0 months). At 1, 2, and 3 years after surgery, the LTP rates were 4.3, 13.1, and 30.4%, respectively, and the OS rates were 89.1, 71.7, and 56.5%, respectively.

conclusionDynaCT-guided TACE + RFA is safe and feasible for the treatment of solitary large HCCS. TACE combined with simultaneous RFA provides a new treatment option for solitary large HCCs in which DynaCT has important clinical value.

Indexed as

AdultAgedCarcinoma, HepatocellularChemoembolization, TherapeuticCombined Modality TherapyDisease ProgressionFemaleHumansKaplan-Meier EstimateLiver NeoplasmsMaleMiddle AgedOperative TimeRadiation DosageRadiofrequency AblationRetrospective StudiesDynaCTHepatocellular carcinomaInterventional radiologyTherapeutic embolization

Identifiers

PMID30132184
PMCPMC6339665

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.