ArticleJournal of assisted reproduction and genetics2018
The effect of female body mass index on in vitro fertilization cycle outcomes: a multi-center analysis.
Article in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- When Weight Matters: How Obesity Impacts Reproductive Health and Pregnancy-A Systematic Review.Current obesity reports · 2025Pooled it
- Association between abnormal body mass index and pregnancy outcomes in patients following frozen embryo transfer: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2021Pooled it
- Modeling Diagnosis and Clinical Outcomes in Infertility Couples Considering Multiple Factors: A Retrospective Study.International journal of fertility & sterility · 2026Article
- Impact of trigger-day serum luteinizing hormone levels on embryo quality and pregnancy outcomes in overweight and obese women undergoing GnRH antagonist protocols: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Peripheral organ crosstalk in the regulation of ovarian endocrine function and reproductive homeostasis.Life medicine · 2025Review
- Adverse effects of maternal and paternal body mass index on assisted reproductive techniques outcomes: A time-lapse study.Clinical and experimental reproductive medicine · 2025Article
- Impact of race and ethnicity on in vitro fertilization outcomes in infertile women with polycystic ovary syndrome in the United States.F&S reports · 2025Article
- The relevance of female overweight in infertility treatment: a position statement of the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR).Journal of assisted reproduction and genetics · 2025Article
- The impact of obesity on reproductive health and metabolism in reproductive-age females.Fertility and sterility · 2024Review
- Overweight and obesity determined by body mass index criteria for Asian populations adversely affect assisted reproductive outcomes among Chinese women with polycystic ovary syndrome.International journal of obesity (2005) · 2024Article
- Article
- Maternal body mass index is not associated with assisted reproductive technology outcomes.Scientific reports · 2023Article
- The influence of male and female overweight/obesity on IVF outcomes: a cohort study based on registration in Western China.Reproductive health · 2023Article
- Associations between obesity, smoking behaviors, reproductive traits and spontaneous abortion: a univariable and multivariable Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Article
- Review
- Preconception Dietary Patterns and Associations With IVF Outcomes: An Ongoing Prospective Cohort Study.Frontiers in nutrition · 2022Article
- Overweight and obesity significantly reduce pregnancy, implantation, and live birth rates in women undergoing In Vitro Fertilization procedures.JBRA assisted reproduction · 2021Article
- Cumulative delivery rate per aspiration IVF/ICSI cycle in POSEIDON patients: a real-world evidence study of 9073 patients.Human reproduction (Oxford, England) · 2021Article
- Low Prognosis by the POSEIDON Criteria in Women Undergoing Assisted Reproductive Technology: A Multicenter and Multinational Prevalence Study of Over 13,000 Patients.Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study is to examine the impact of female body mass index (BMI) on IVF cycle outcomes.
methodsThis is a retrospective cohort study including 51,198 women who initiated their first autologous IVF cycle in 13 fertility centers in the USA between 2009 and 2015. The effect of underweight, overweight, and obese BMI on four different IVF cycle outcomes (cycle cancellation, oocyte and embryo counts, and ongoing clinical pregnancy [OCP]) was evaluated in logistic or Poisson regression analyses with confounders adjusted.
resultsWomen with an overweight or obese BMI experienced worse outcomes than those with a normal BMI. These differences included (1) greater odds of cycle cancellation (aOR [95%CI] 1.17 [1.08, 1.26] for overweight, 1.28 [1.15, 1.41] for class-I obesity, and 1.50 [1.33, 1.68] for class-II/III obesity, P < .001 for all); (2) fewer oocytes retrieved (aIRR [95%CI] 0.98 [0.98,0.99] for class-I obesity, 0.93 [0.92,0.94] for class-II/III obesity, P < .001 for both); (3) fewer usable embryos (aIRR [95%CI] 0.98 [0.97,0.99] for overweight, 0.97 [0.96,0.99] for class-I obesity, 0.95 [0.93,0.97] for class-II/III obesity, P < .01 for all); and (4) lower odds of OCP (aOR [95%CI] 0.89 [0.83,0.95] for class-I obesity, 0.86 [0.79,0.93] for class-II/III obesity, P < .001 for both). In a subgroup analysis based on primary infertility diagnosis, these trends persisted in those with male or uterine factor and were especially pronounced in women with ovulatory dysfunction or PCOS.
conclusionsA BMI above the normal range was an independent negative prognostic factor for multiple outcomes, including cycle cancellation, oocyte and embryo counts, and OCP. These negative outcomes were most profound in women with class-II/III obesity, ovulatory dysfunction, or PCOS.
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