Evidence map›Paper›PMID 30132130›Full record

ArticleVirchows Archiv : an international journal of pathology2019

CD200 expression is a feature of solid pseudopapillary neoplasms of the pancreas.

Rita T Lawlor, Valentina Daprà, Ilaria Girolami, Antonio Pea, Camilla Pilati, Alessia Nottegar, Paola Piccoli, Claudia Parolini, Nicola Sperandio, Paola Capelli and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Rita T LawlorARC-Net Research Center, University of Verona, Verona, Italy.
Valentina DapràDepartment of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Piazzale Scuro, 10, 37134, Verona, Italy.
Ilaria GirolamiDepartment of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Piazzale Scuro, 10, 37134, Verona, Italy.
Antonio PeaDepartment of General and Visceral Surgery, Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy.
Camilla PilatiPersonalized Medicine, Pharmacogenomics, Therapeutic Optimization, Paris-Descartes University, Paris, France.
Alessia NottegarDepartment of Surgery, Section of Pathology, San Bortolo Hospital, Vicenza, Italy.
Paola PiccoliDepartment of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Piazzale Scuro, 10, 37134, Verona, Italy.
Claudia ParoliniDepartment of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Piazzale Scuro, 10, 37134, Verona, Italy.
Nicola SperandioDepartment of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Piazzale Scuro, 10, 37134, Verona, Italy.
Paola CapelliDepartment of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Piazzale Scuro, 10, 37134, Verona, Italy.
Aldo ScarpaARC-Net Research Center, University of Verona, Verona, Italy. aldo.scarpa@univr.it.
Claudio LuchiniDepartment of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Piazzale Scuro, 10, 37134, Verona, Italy.
University of Verona · ITOspedale San Bortolo · ITUniversité Paris Cité · FR

Funding

Associazione Italiana per la Ricerca sul Cancro 12182FP7 European Community Grant Cam-Pac 602783
6 · The paper itself

Abstract

CD200 has been recently indicated as a robust marker of well-differentiated neuroendocrine neoplasms. Here, we evaluate its role in differential diagnosis of solid pancreatic neoplasms. We immunostained for CD200 22 solid pseudopapillary neoplasms (SPNs), 8 acinar carcinomas (ACs), 2 pancreatoblastomas (PBs), 138 neuroendocrine tumors (PanNETs), and 48 ductal adenocarcinomas. All SPNs showed strong cytoplasmic and membranous staining for CD200, while only one case of AC had focal positivity. The two PBs showed focal CD200 positivity, mainly located in squamoid nests. The vast majority of PanNETs (96%) showed strong cytoplasmic and membranous staining for CD200, whereas all PDACs were negative. As both PanNETs and SPNs express CD200, it has no role in the differential diagnosis between these two entities.

Indexed as

Antigens, CDBiomarkers, TumorCarcinoma, Acinar CellCarcinoma, Pancreatic DuctalCarcinoma, PapillaryDiagnosis, DifferentialHumansImmunohistochemistryNeuroendocrine TumorsPancreatic NeoplasmsPredictive Value of TestsAntigens, CDantigens, CD200Biomarkers, TumorAcinar carcinomaCD200ImmunohistochemistryPancreatic cancerSPNSPT

Identifiers

PMID30132130
PMCPMC6323071
OpenAlexW2888033729

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.