ArticleClinical neuroradiology2019
MDCT-based Finite Element Analysis of Vertebral Fracture Risk: What Dose is Needed?
Article in Clinical neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Computed Tomography of the Spine : Systematic Review on Acquisition and Reconstruction Techniques to Reduce Radiation Dose.Clinical neuroradiology · 2023Pooled it
- Integrating radiomics with clinical data for enhanced prediction of vertebral fracture risk.Frontiers in bioengineering and biotechnology · 2024Article
- Characterization of mechanical stiffness using additive manufacturing and finite element analysis: potential tool for bone health assessment.3D printing in medicine · 2023Article
- Finite Element Analysis of Osteoporotic and Osteoblastic Vertebrae and Its Association With the Proton Density Fat Fraction From Chemical Shift Encoding-Based Water-Fat MRI - A Preliminary Study.Frontiers in endocrinology · 2022Article
- MDCT-Based Finite Element Analysis for the Prediction of Functional Spine Unit Strength-An In Vitro Study.Materials (Basel, Switzerland) · 2021Article
- Multi-detector computed tomography (MDCT) imaging: association of bone texture parameters with finite element analysis (FEA)-based failure load of single vertebrae and functional spinal units.Quantitative imaging in medicine and surgery · 2021Article
- MDCT-Based Finite Element Analyses: Are Measurements at the Lumbar Spine Associated with the Biomechanical Strength of Functional Spinal Units of Incidental Osteoporotic Fractures along the Thoracolumbar Spine?Diagnostics (Basel, Switzerland) · 2021Article
- Prediction of Incidental Osteoporotic Fractures at Vertebral-Specific Level Using 3D Non-Linear Finite Element Parameters Derived from Routine Abdominal MDCT.Diagnostics (Basel, Switzerland) · 2021Article
- X-ray-based quantitative osteoporosis imaging at the spine.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Review
- Finite Element Analysis-Based Vertebral Bone Strength Prediction Using MDCT Data: How Low Can We Go?Frontiers in endocrinology · 2020Article
- Predicting Vertebral Bone Strength Using Finite Element Analysis for Opportunistic Osteoporosis Screening in Routine Multidetector Computed Tomography Scans-A Feasibility Study.Frontiers in endocrinology · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
purposeThe aim of this study was to compare vertebral failure loads, predicted from finite element (FE) analysis of patients with and without osteoporotic vertebral fractures (OVF) at virtually reduced dose levels, compared to standard-dose exposure from multidetector computed tomography (MDCT) imaging and evaluate whether ultra-low dose derived FE analysis can still differentiate patient groups. MATERIALS AND
methodsAn institutional review board (IRB) approval was obtained for this retrospective study. A total of 16 patients were evaluated at standard-dose MDCT; eight with and eight without OVF. Images were reconstructed at virtually reduced dose levels (i. e. half, quarter and tenth of the standard dose). Failure load was determined at L1-3 from FE analysis and compared between standard, half, quarter, and tenth doses and used to differentiate between fracture and control groups.
resultsFailure load derived at standard dose (3254 ± 909 N and 3794 ± 984 N) did not significantly differ from half (3390 ± 890 N and 3860 ± 1063 N) and quarter dose (3375 ± 915 N and 3925 ± 990 N) but was significantly higher for one tenth dose (4513 ± 1762 N and 4766 ± 1628 N) for fracture and control groups, respectively. Failure load differed significantly between the two groups at standard, half and quarter doses, but not at tenth dose. Receiver operating characteristic (ROC) curve analysis also demonstrated that standard, half, and quarter doses can significantly differentiate the fracture from the control group.
conclusionThe use of MDCT enables a dose reduction of at least 75% compared to standard-dose for an adequate prediction of vertebral failure load based on non-invasive FE analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.