Evidence map›Paper›PMID 30132083›Full record

ArticleCancer immunology, immunotherapy : CII2018

Determination of optimum vitamin D3 levels for NK cell-mediated rituximab- and obinutuzumab-dependent cellular cytotoxicity.

Frank Neumann, Fabian Acker, Claudia Schormann, Michael Pfreundschuh, Joerg Thomas Bittenbring

Open access · hybridAbstract read
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Frank NeumannJosé Carreras Center for Immuno and Gene Therapy, Saarland University, Homburg, Saarland, Germany.ORCID http://orcid.org/0000-0002-5669-0421
Fabian AckerDepartment of Internal Medicine I, Saarland University Medical Center, Kirrberger Strasse 100, 66421, Homburg, Saarland, Germany.
Claudia SchormannJosé Carreras Center for Immuno and Gene Therapy, Saarland University, Homburg, Saarland, Germany.
Michael PfreundschuhDepartment of Internal Medicine I, Saarland University Medical Center, Kirrberger Strasse 100, 66421, Homburg, Saarland, Germany.
Joerg Thomas BittenbringDepartment of Internal Medicine I, Saarland University Medical Center, Kirrberger Strasse 100, 66421, Homburg, Saarland, Germany. Joerg.Thomas.Bittenbring@uks.eu.
Saarland University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D3 (25-OH-D3) deficiency impairs rituximab-dependent cellular cytotoxicity and the outcome of patients with diffuse large B-cell and follicular lymphomas (DLBCL). Since the optimum 25-OH-D3 serum levels for NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) are unknown, we determined the 25-OH-D3 serum levels associated with maximum NK cell-mediated ADCC. CD20 antibody-loaded CD20

Indexed as

AdultAgedAged, 80 and overAntibodies, Monoclonal, HumanizedAntibody-Dependent Cell CytotoxicityAntineoplastic Agents, ImmunologicalCase-Control StudiesCholecalciferolCytotoxicity, ImmunologicFemaleHealthy VolunteersHumansKiller Cells, NaturalLymphocyte ActivationLymphoma, Large B-Cell, DiffuseMaleAntibodies, Monoclonal, HumanizedAntineoplastic Agents, ImmunologicalCholecalciferolobinutuzumabRituximabADCCLymphomaNK cellsObinutuzumabRituximabVitamin D3

Identifiers

PMID30132083
PMCPMC11028244
OpenAlexW2888056294

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.