ReviewPediatric nephrology (Berlin, Germany)2019
Primary vesicoureteral reflux; what have we learnt from the recently published randomized, controlled trials?
Review in Pediatric nephrology (Berlin, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- A novel clinical score to predict breakthrough urinary tract infection in children with VUR: meta-analytic derivation and real-world validation.Pediatric nephrology (Berlin, Germany) · 2026Pooled it
- Is uromodulin a reliable biomarker in pediatric vesicoureteral reflux? An exploratory pilot study.International urology and nephrology · 2026Article
- Diagnostic performance of contrast-enhanced voiding ultrasonography and direct radionuclide cystography with physiologic bladder filling volumes in pediatric vesicoureteral reflux-a prospective study.European journal of pediatrics · 2026Article
- Recent Developments in Pediatric Nephrology.Journal of clinical medicine · 2025Article
- Molecular analysis of acute pyelonephritis-excessive innate and attenuated adaptive immunity.Life science alliance · 2025Article
- Review
- Long-term consequences of urinary tract infection in childhood: an electronic population-based cohort study in Welsh primary and secondary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2024Article
- Conflicting views of physicians and surgeons concerning pediatric urinary tract infection: a comparative review.Pediatric radiology · 2023Review
- Unveiling the Hidden Power of Uromodulin: A Promising Potential Biomarker for Kidney Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- Vesicoscopic vs. Open Ureteral Reimplantation According to Cohen and Leadbetter-Politano for Vesicoureteral Reflux.Journal of clinical medicine · 2023Article
- Uromodulin and Vesico-Ureteral Reflux: A Genetic Study.Biomedicines · 2023Article
- Management of the congenital solitary kidney: consensus recommendations of the Italian Society of Pediatric Nephrology.Pediatric nephrology (Berlin, Germany) · 2022Review
- Preserved Voluntary Micturition Control despite Early Urinary Diversion in Infancy-A Clue to a New Strategy.Children (Basel, Switzerland) · 2022Article
- Imaging in Febrile Urinary Tract Infections - Area of Debate: Correspondence.Indian journal of pediatrics · 2021Article
- Types of Parenchymal Changes Diagnosed on DMSA Scans of Kidneys Affected by Different Grades of Vesicoureteral Reflux.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Prenatal and postnatal urinary tract dilation: advantages of a standardized ultrasound definition and classification.Journal of ultrasound · 2019Review
- Congenital Anomalies of the Kidney and Urinary Tract: A Clinical Review.Current treatment options in pediatrics · 2019Article
- Antibiotic prophylaxis in infants with Grade III, IV, or V vesicoureteral reflux.Indian journal of urology : IJU : journal of the Urological Society of IndiaArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, progress has been made on understanding the relationship between vesicoureteral reflux (VUR) and urinary tract infection (UTI). The findings on recent prospective, randomized, controlled studies have questioned the conventional VUR clinical significance and, therefore, have challenged the traditional diagnostic and therapeutic recommendations. These new studies have redefined the pathogenic role of vesicoureteral reflux in UTI as well as have disputed the routine use of urinary antibiotic prophylaxis to prevent UTI and renal damage in VUR patients. The time to overinvestigate and treat the vast majority of otherwise healthy children who have an uncomplicated UTI with long-term antibiotic prophylaxis seems to be over. Is there a role of severe VUR in the development of chronic renal disease and renal failure? New ideas are needed to answer these questions with the goal to avoid repeating past mistakes when therapeutic choices were based on expert opinions rather than facts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.