ArticleLab on a chip2018
High-throughput cell focusing and separation via acoustofluidic tweezers.
Article in Lab on a chip, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Acoustic technologies for the orchestration of cellular functions for therapeutic applications.Science advances · 2025Review
- High-Performance and Environmentally-Friendly Bulk-Wave-Acoustofluidic Devices Driven by Lead-Free Piezoelectric Materials.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Microfluidic Nanoparticle Separation for Precision Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Exploring operational boundaries for acoustic concentration of cell suspensions.Applied microbiology and biotechnology · 2024Article
- Acoustofluidic Actuation of Living Cells.Micromachines · 2024Review
- Simplified 3D hydrodynamic flow focusing for lab-on-chip single particle study.Scientific reports · 2023Article
- Sheathless inertial particle focusing methods within microfluidic devices: a review.Frontiers in bioengineering and biotechnology · 2023Review
- A Hybrid Spiral Microfluidic Platform Coupled with Surface Acoustic Waves for Circulating Tumor Cell Sorting and Separation: A Numerical Study.Biosensors · 2022Article
- Recent advances in acoustofluidic separation technology in biology.Microsystems & nanoengineering · 2022Review
- Delivering the CRISPR/Cas9 system for engineering gene therapies: Recent cargo and delivery approaches for clinical translation.Frontiers in bioengineering and biotechnology · 2022Review
- Acoustic tweezing of microparticles in microchannels with sinusoidal cross sections.Scientific reports · 2021Article
- Fluorescence-based sorting of Caenorhabditis elegans via acoustofluidics.Lab on a chip · 2020Article
- Article
- The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review.Micromachines · 2020Review
- Acoustic Cell Separation Based on Density and Mechanical Properties.Journal of biomechanical engineering · 2020Article
- Cell Separations and Sorting.Analytical chemistry · 2020Review
- On-chip integrated optical stretching and electrorotation enabling single-cell biophysical analysis.Microsystems & nanoengineering · 2020Article
- On-chip stool liquefaction via acoustofluidics.Lab on a chip · 2019Article
- Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separation.Lab on a chip · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
Separation of particles and cells is an important function in many biological and biomedical protocols. Although a variety of microfluidic-based techniques have been developed so far, there is clearly still a demand for a precise, fast, and biocompatible method for separation of microparticles and cells. By combining acoustics and hydrodynamics, we have developed a method which we integrated into three-dimensional acoustofluidic tweezers (3D-AFT) to rapidly and efficiently separate microparticles and cells into multiple high-purity fractions. Compared with other acoustophoresis methods, this 3D-AFT method significantly increases the throughput by an order of magnitude, is label-free and gently handles the sorted cells. We demonstrate not only the separation of 10, 12, and 15 micron particles at a throughput up to 500 μl min-1 using this 3D-AFT method, but also the separation of erythrocytes, leukocytes, and cancer cells. This 3D-AFT method is able to meet various separation demands thus offering a viable alternative with potential for clinical applications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.