Evidence map›Paper›PMID 30131849›Full record

ArticleOncotarget2018

Chromatin-associated APC regulates gene expression in collaboration with canonical WNT signaling and AP-1.

William Hankey, Zhong Chen, Maxwell J Bergman, Max O Fernandez, Baris Hancioglu, Xun Lan, Anil G Jegga, Jie Zhang, Victor X Jin, Bruce J Aronow and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

William HankeyDepartment of Cancer Biology and Genetics, The Ohio State University College of Medicine, Columbus, Ohio, United States of America.
Zhong ChenDepartment of Pathology, Duke University School of Medicine, Durham, North Carolina, United States of America.
Maxwell J BergmanDepartment of Cancer Biology and Genetics, The Ohio State University College of Medicine, Columbus, Ohio, United States of America.
Max O FernandezDepartment of Cancer Biology and Genetics, The Ohio State University College of Medicine, Columbus, Ohio, United States of America.
Baris HanciogluBiomedical Informatics Shared Resource, The Ohio State University, Columbus, Ohio, United States of America.
Xun LanDepartment of Basic Medical Sciences, Tsinghua University School of Medicine, Beijing, China.
Anil G JeggaDivision of Bioinformatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.
Jie ZhangDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.
Victor X JinDepartment of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America.
Bruce J AronowDivision of Bioinformatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.
Qianben WangDepartment of Pathology, Duke University School of Medicine, Durham, North Carolina, United States of America.
Joanna GrodenDepartment of Cancer Biology and Genetics, The Ohio State University College of Medicine, Columbus, Ohio, United States of America.
The Ohio State University · USCincinnati Children's Hospital Medical Center · USDuke University · USIndiana University School of MedicineThe University of Texas Health Science Center at San Antonio · USTsinghua University · CN

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4M
The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
CHARACTERIZATION OF TUMOR SUPPRESSION BY THE APC GENER01CA063507 · NCI · UNIVERSITY OF CINCINNATI · PI GRODEN, JOANNA LOUISE · 2000 to 2010
$2.7M
Chromatin associated functions of the APC tumor suppressorF31CA174260 · NCI · OHIO STATE UNIVERSITY · PI HANKEY, WILLIAM CHARLES · 2013 to 2015
$76k
NCATS NIH HHS UL1 TR001070NCI NIH HHS F31 CA174260NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA063507NIDDK NIH HHS P30 DK078392
6 · The paper itself

Abstract

Mutation of the

Indexed as

AP-1APCcanonical WNT signalingchromatincolorectal cancer

Identifiers

PMID30131849
PMCPMC6101278
OpenAlexW2884606386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.