Evidence map›Paper›PMID 30131802›Full record

ArticleFrontiers in immunology2018

Circulating Follicular Helper and Follicular Regulatory T Cells Are Severely Compromised in Human CD40 Deficiency: A Case Report.

Maria Pia Cicalese, Jolanda Gerosa, Manuela Baronio, Davide Montin, Francesco Licciardi, Annarosa Soresina, Rosa Maria Dellepiane, Maurizio Miano, Lucia Augusta Baselli, Stefano Volpi and 5 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. [A case of hepatitis-associated aplastic anemia complicated by hemophagocytic lymphohistiocytosis and literature review].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
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  12. A Prevalent CXCR3Journal of clinical immunology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Maria Pia CicaleseSan Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Jolanda GerosaDivision of Immunology Transplantation and Infectious Diseases (DITID), Diabetes Research Institute (DRI) IRCCS San Raffaele Scientific Institute, Milan, Italy.
Manuela BaronioDepartment of Clinical and Experimental Sciences, Pediatrics Clinic and Institute of Molecular Medicine A. Novicelli, University of Brescia, ASST-Spedali Civili of Brescia, Brescia, Italy.
Davide MontinImmuno-Rheumatology, Department of Paediatrics II, Regina Margherita Hospital, Città della Salute e della Scienza di Torino, Torino, Italy.
Francesco LicciardiImmuno-Rheumatology, Department of Paediatrics II, Regina Margherita Hospital, Città della Salute e della Scienza di Torino, Torino, Italy.
Annarosa SoresinaPediatrics Clinic, ASST-Spedali Civili di Brescia, Brescia, Italy.
Rosa Maria DellepianeDepartment of Pediatrics, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
Maurizio MianoDepartment of Emato-Oncology, IRCCS Instituto Giannina Gaslini, Genoa, Italy.
Lucia Augusta BaselliDepartment of Pediatrics, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
Stefano VolpiDepartment of Pediatrics, IRCCS Instituto Giannina Gaslini, Genoa, Italy.
Carlo DufourDepartment of Emato-Oncology, IRCCS Instituto Giannina Gaslini, Genoa, Italy.
Alessandro PlebaniDepartment of Clinical and Experimental Sciences, Pediatrics Clinic and Institute of Molecular Medicine A. Novicelli, University of Brescia, ASST-Spedali Civili of Brescia, Brescia, Italy.
Alessandro AiutiSan Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Vassilios LougarisDepartment of Clinical and Experimental Sciences, Pediatrics Clinic and Institute of Molecular Medicine A. Novicelli, University of Brescia, ASST-Spedali Civili of Brescia, Brescia, Italy.
Georgia FousteriDivision of Immunology Transplantation and Infectious Diseases (DITID), Diabetes Research Institute (DRI) IRCCS San Raffaele Scientific Institute, Milan, Italy.
University of Brescia · ITVita-Salute San Raffaele University · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITIstituto Giannina Gaslini · ITOspedale Regina Margherita · ITUniversity of Milan · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in genes that control class switch recombination and somatic hypermutation during the germinal center (GC) response can cause diverse immune dysfunctions. In particular, mutations in

Indexed as

AdolescentAdultAICDA (Activation-Induced Cytidine Deaminase)CD40 AntigensCD40 LigandChild, PreschoolCytidine DeaminaseFemaleHumansHyper-IgM Immunodeficiency SyndromeImmunophenotypingLymphocyte ActivationMaleMutationT-Lymphocytes, Helper-InducerT-Lymphocytes, RegulatoryAICDA (Activation-Induced Cytidine Deaminase)CD40 AntigensCD40 LigandCytidine DeaminaseAICDACD40CD40LGclass switch recombinationfollicular helper T cellsfollicular regulatory T cellshyper-IgM syndromesomatic hypermutation

Identifiers

PMID30131802
PMCPMC6090258
OpenAlexW2885645939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.