Evidence map›Paper›PMID 30131800›Full record

ArticleFrontiers in immunology2018

Predictable Irreversible Switching Between Acute and Chronic Inflammation.

Abulikemu Abudukelimu, Matteo Barberis, Frank A Redegeld, Nilgun Sahin, Hans V Westerhoff

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Abulikemu AbudukelimuDepartment of Synthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands.
Matteo BarberisDepartment of Synthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands.
Frank A RedegeldDivision of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.
Nilgun SahinDepartment of Molecular Cell Physiology, VU University Amsterdam, Amsterdam, Netherlands.
Hans V WesterhoffDepartment of Synthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands.
University of Amsterdam · NLUniversity of Manchester · GBUtrecht University · NL

Funding

Biotechnology and Biological Sciences Research Council BB/I004688/1Biotechnology and Biological Sciences Research Council BB/J020060/1
6 · The paper itself

Abstract

Many a disease associates with inflammation. Upon binding of antigen-antibody complexes to immunoglobulin-like receptors, mast cells release tumor necrosis factor-α and proteases, causing fibroblasts to release endogenous antigens that may be cross reactive with exogenous antigens. We made a predictive dynamic map of the corresponding extracellular network.

Indexed as

Models, ImmunologicalAcute DiseaseAnimalsChronic DiseaseHumansInflammationMetabolic Networks and PathwaysProtein Interaction Mapsbi-stabilitycross-reacting antigeninflammationinnate immunityirreversible transitionmodeling

Identifiers

PMID30131800
PMCPMC6090016
OpenAlexW2811310601

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.