ArticleFrontiers in physiology2018
Oxidative Stress Mediates Microcystin-LR-Induced Endoplasmic Reticulum Stress and Autophagy in KK-1 Cells and C57BL/6 Mice Ovaries.
Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 51 citations in OpenAlex.
- Review
- PU.1 aggravates hepatic sinusoidal obstruction syndrome by upregulating PTBP1 and activating the Wnt/β-catenin pathway.Histology and histopathology · 2026Article
- Female reproductive impacts of emerging cyanobacterial harmful algal bloom toxins.The Journal of reproduction and development · 2026Review
- Effects of Melatonin and 3,5,3'-Triiodothyronine on the Development of Rat Granulosa Cells.Nutrients · 2024Article
- Hepatic NLRP3-Derived Hsp70 Binding to TLR4 Mediates MASLD to MASH Progression upon Inhibition of PP2A by Harmful Algal Bloom Toxin Microcystin, a Second Hit.International journal of molecular sciences · 2023Article
- Article
- Initiation and elongation factor co-expression correlates with recurrence and survival in epithelial ovarian cancer.Journal of ovarian research · 2022Article
- NRF2-mediated signaling is a master regulator of transcription factors in bovine granulosa cells under oxidative stress condition.Cell and tissue research · 2021Article
- Curcumin Ameliorates Palmitic Acid-Induced Saos-2 Cell Apoptosis Via Inhibiting Oxidative Stress and Autophagy.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Global transcriptomic profiling of microcystin-LR or -RR treated hepatocytes (HepaRG).Toxicon: X · 2020Article
- Anticancer effect of caudatin in diethylnitrosamine‑induced hepatocarcinogenesis in rats.Molecular medicine reports · 2020Article
- Fucoidan alleviates microcystin-LR-induced hepatic, renal, and cardiac oxidative stress and inflammatory injuries in mice.Environmental science and pollution research international · 2020Article
- Hydrogen Sulfide Signaling ProtectsFrontiers in plant science · 2020Article
- Vitamin C Protects Porcine Oocytes From Microcystin-LR Toxicity During Maturation.Frontiers in cell and developmental biology · 2020Article
- Melatonin attenuates palmitic acid-induced mouse granulosa cells apoptosis via endoplasmic reticulum stress.Journal of ovarian research · 2019Article
- Astragaloside IV ameliorates endoplasmic reticulum stress‑induced apoptosis of Aβ25‑35‑treated PC12 cells by inhibiting the p38 MAPK signaling pathway.Molecular medicine reports · 2019Article
- Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence.Frontiers in endocrinology · 2019Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microcystin-leucine arginine (MC-LR) is a cyclic heptapeptide intracellular toxin released by cyanobacteria that exhibits strong reproductive toxicity. However, little is known about its biotoxicity to the female reproductive system. The present study investigates unexplored molecular pathways by which oxidative stress acts on MC-LR-induced endoplasmic reticulum stress (ERs) and autophagy. In the present study, immortalized murine ovarian granular cells (KK-1 cells) were exposed to 8.5, 17, and 34 μg/mL (IC
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Registered trials
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