ArticleFrontiers in physiology2018
Pain Control by Proprioceptive and Exteroceptive Stimulation at the Trigeminal Level.
Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Effectiveness of Audiovisual Distraction During Dental Treatment Under Nitrous Oxide/Oxygen Conscious Sedation in Paediatric Patients: A Randomized Crossover Clinical Trial.Children (Basel, Switzerland) · 2026Article
- Manual therapy combined with core muscle training for chronic non-specific low back pain in sedentary individuals: a study protocol for a single-center randomized controlled trial.Frontiers in medicine · 2026Article
- Neurobehavioral profile of individuals with pathogenic variants in CHD3.European journal of human genetics : EJHG · 2025Article
- Cortical Reorganization after Limb Loss: Bridging the Gap between Basic Science and Clinical Recovery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Effectiveness of Focal Muscle Vibration in the Recovery of Neuromotor Hypofunction: A Systematic Review.Journal of functional morphology and kinesiology · 2023Review
- Somatosensory cortical signature of facial nociception and vibrotactile touch-induced analgesia.Science advances · 2022Article
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Authors and funding
5 authors.
Funding
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Abstract
The Gate Control Theory of pain, published more than half a century ago to explain nociceptive modulation of peripheral sensory input, assumes inhibition of incoming nociceptive (pain) information produced by mechanical stimulation. To verify the presence of such a gate control mechanism at the level of the human trigeminal system, we evaluated the effects on pain sensation of a proprioceptive trigeminal stimulation induced by mandibular extension. We found that such a stimulation, applied for 7 min, was effective in increasing both the threshold and tolerance of tooth pain induced by electrical activation of dental nociceptors. Moreover the antinociceptive effect lasted for several minutes after the proprioceptive stimulus had ceased. We also tested whether an exteroceptive palatal stimulation superimposed on the proprioceptive stimulation would increase the effects on tooth pain perception of human volunteers. We observed that the exteroceptive stimulation significantly increased the antinociceptive effect induced by the sole proprioceptive stimulation. The physiological mechanisms and the possible implications of these observations are discussed.
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