ArticleFrontiers in physiology2018
Tuning RGD Motif and Hyaluronan Density to Study Integrin Binding.
Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Design and Synthesis of Porphyrin-Nitrilotriacetic Acid Dyads with Potential Applications in Peptide Labeling through Metallochelate Coupling.ACS omega · 2022Article
- Aquaporin-Incorporated Graphene-Oxide Membrane for Pressurized Desalination with Superior Integrity Enabled by Molecular Recognition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- A Review on the Enhancement of Calcium Phosphate Cement with Biological Materials in Bone Defect Healing.Polymers · 2021Review
- Anti-Tumor Activity and Pharmacokinetics of AP25-Fc Fusion Protein.International journal of medical sciences · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Well-controlled surfaces with immobilized substrates enable novel approaches to investigate specific aspects of biological processes related to cell adhesion or motility. A subset of integrins, cellular transmembrane glycoproteins, recognize the evolutionarily conserved tripeptide sequence RGD, and anchor cells to their surrounding proteins as well as mediate bidirectional signaling. In this study, the main question was how co-presentation of hyaluronan (HA), an essential component of the extracellular matrix (ECM), and the RGD motif affect integrin binding. We report a method to prepare self-assembled monolayers on gold surfaces, co-presenting the cell adhesive RGD motif and small HA molecules, to investigate integrin containing proteoliposome binding. This technique enables an independent adjustment of the RGD motif and HA density while maintaining a passivating background: Layer formation and subsequent interactions with α
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Registered trials
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