Evidence map›Paper›PMID 30131658›Full record

ReviewWorld journal of gastroenterology2018

Ubiquitin-proteasome system and oxidative stress in liver transplantation.

Norma Alva, Arnau Panisello-Roselló, Marta Flores, Joan Roselló-Catafau, Teresa Carbonell

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The Role of HECT-Type E3 Ligase in the Development of Cardiac Disease.International journal of molecular sciences · 2021
    Review
  9. Research progress on hepatic machine perfusion.International journal of medical sciences · 2021
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Norma AlvaDepartment of Cell Biology, Physiology and Immunology, University of Barcelona, Barcelona 08028, Spain.
Arnau Panisello-RosellóExperimental Pathology Department, Institute of Biomedical Research of Barcelona, Barcelona 08036, Spain.
Marta FloresDepartment of Cell Biology, Physiology and Immunology, University of Barcelona, Barcelona 08028, Spain.
Joan Roselló-CatafauExperimental Pathology Department, Institute of Biomedical Research of Barcelona, Barcelona 08036, Spain.
Teresa CarbonellDepartment of Cell Biology, Physiology and Immunology, University of Barcelona, Barcelona 08028, Spain. tcarbonell@ub.edu.
Institut d'Investigacions Biomèdiques de Barcelona · ESUniversitat de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A major issue in organ transplantation is the development of a protocol that can preserve organs under optimal conditions. Damage to organs is commonly a consequence of flow deprivation and oxygen starvation following the restoration of blood flow and reoxygenation. This is known as ischemia-reperfusion injury (IRI): a complex multifactorial process that causes cell damage. While the oxygen deprivation due to ischemia depletes cell energy, subsequent tissue oxygenation due to reperfusion induces many cascades, from reactive oxygen species production to apoptosis initiation. Autophagy has also been identified in the pathogenesis of IRI, although such alterations and their subsequent functional significance are controversial. Moreover, proteasome activation may be a relevant pathophysiological mechanism. Different strategies have been adopted to limit IRI damage, including the supplementation of commercial preservation media with pharmacological agents or additives. In this review, we focus on novel strategies related to the ubiquitin proteasome system and oxidative stress inhibition, which have been used to minimize damage in liver transplantation.

Indexed as

AnimalsApoptosisAutophagyEnd Stage Liver DiseaseHumansLiverLiver TransplantationOrgan PreservationOrgan Preservation SolutionsOxidative StressProteasome Endopeptidase ComplexProteasome InhibitorsReperfusion InjuryUbiquitinUbiquitinationOrgan Preservation SolutionsProteasome Endopeptidase ComplexProteasome InhibitorsUbiquitinIschemia-reperfusion injuryLiver transplantOxidative stressProteasomeRedox regulationUbiquitin

Identifiers

PMID30131658
PMCPMC6102496
OpenAlexW2885262356

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.