ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018
Striato-cortical tracts predict 12-h abstinence-induced lapse in smokers.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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27 citing papers in PubMed, 51 citations in OpenAlex.
- Sex differences in tobacco smokers: Executive control network and frontostriatal connectivity.Drug and alcohol dependence · 2019Trial
- The Phase-Amplitude Coupling Changes Induced by Smoking Cue After 12-H Abstinence in Young Smokers.Addiction biology · 2025Article
- Repetitive transcranial magnetic stimulation reduces nicotine dependence and potentially modulates white matter microstructure in smokers: a pilot study by diffusion spectrum imaging.Frontiers in neurology · 2025Article
- Meso-cortical pathway damage in cognition, apathy and gait in cerebral small vessel disease.Brain : a journal of neurology · 2024Article
- Altered Brain Structure in Hemifacial Spasm Patients: A Multimodal Brain Structure Study.International journal of general medicine · 2024Article
- The Abnormal N-Acetylaspartate to Creatine Ratio of the Right Putamen is Linked to Wakefulness in Patients with Insomnia Disorder.Nature and science of sleep · 2024Article
- Implications of neuroimaging findings in addiction.Psychoradiology · 2023Review
- Neuroeconomic predictors of smoking cessation outcomes: A preliminary study of delay discounting in treatment-seeking adult smokers.Psychiatry research. Neuroimaging · 2022Article
- Effects of Smoking Status and State on Intrinsic Connectivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Abnormal hippocampal substructure volume in insomnia disorder.Brain imaging and behavior · 2022Article
- Comparison of frontostriatal circuits in adolescent nicotine addiction and internet gaming disorder.Journal of behavioral addictions · 2022Review
- Altered resting-state electroencephalography microstate characteristics in young male smokers.Frontiers in psychiatry · 2022Article
- Impulsive trait mediates the relationship between white matter integrity of prefrontal-striatal circuits and the severity of dependence in alcoholism.Frontiers in psychiatry · 2022Article
- Psychometric investigation of the Chinese version of the Habit, Reward and Fear Scale (HRFS).Brain and behavior · 2021Article
- Reduced thalamic resting-state functional connectivity and impaired cognition in acute abstinent heroin users.Human brain mapping · 2021Article
- Pictures Library of Smoking Cravings: Development and Verification of Smokers and Non-smokers.Frontiers in psychiatry · 2021Article
- Support vector machine based classification of smokers and nonsmokers using diffusion tensor imaging.Brain imaging and behavior · 2020Article
- Nicotine-induced neuroplasticity in striatum is subregion-specific and reversed by motor training on the rotarod.Addiction biology · 2020Article
- Nicotine dependence (trait) and acute nicotinic stimulation (state) modulate attention but not inhibitory control: converging fMRI evidence from Go-Nogo and Flanker tasks.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Dynamic Neuroimaging Biomarkers of Smoking in Young Smokers.Frontiers in psychiatry · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Striatal circuit dysfunction is implicated in smoking behaviors and lapses during abstinence attempts. However, little is known about whether the structural connectivity of striatal tracts can be used to predict abstinence-induced craving and lapses. The tract strengths of striatal circuits were compared in 53 male nicotine-dependent cigarette smokers and 58 matched nonsmokers, using seed-based classification by diffusion tensor imaging (DTI) probabilistic tractography with 10 a priori target masks. A 12-h abstinence procedure was then employed, after which 31 individuals abstained and 22 lapsed. Linear regression and binary logistic regression was conducted to test whether the tract strength of frontostriatal circuits was associated with craving changes in abstainers and predicted lapse in smokers. Compared with nonsmokers, in the left hemisphere, smokers showed weaker tract strength in striatum-medial orbitofrontal cortex (mOFC), striatum-ventral lateral prefrontal cortex (vlPFC), striatum-inferior frontal gyrus (IFG) and striatum-posterior cingulate cortex (PCC) (Bonferroni corrected, p < 0.05/20 = 0.0025). In abstainers, the abstinence-induced increases in craving were associated with the tract strength of the left striatum-mOFC and striatum-vlPFC. The tract strength of left striatum-dorsolateral PFC (dlPFC) predicted lapse in smokers with an accuracy of 68.3%. These results provide system-level insights into the weaker tract strength of frontostriatal circuits in male smokers and their potential roles as neuroimaging markers for abstinence-induced craving and risk of lapse. Future studies in female smokers are needed to determine if this generalizes across genders.
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