Evidence map›Paper›PMID 30131526›Full record

ArticleScientific reports2018

The small heat shock protein HSPB1 protects mice from sepsis.

Elise R Breed, Carolyn A Hilliard, Benyam Yoseph, Rohit Mittal, Zhe Liang, Ching-Wen Chen, Eileen M Burd, Luke P Brewster, Laura M Hansen, Rudolph L Gleason and 4 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Elise R BreedDepartment of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, GA, Georgia.
Carolyn A HilliardDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Benyam YosephDepartment of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, GA, Georgia.
Rohit MittalDepartment of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, GA, Georgia.
Zhe LiangDepartment of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, GA, Georgia.
Ching-Wen ChenDepartment of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, GA, Georgia.
Eileen M BurdDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, Georgia.
Luke P BrewsterDepartment of Surgery, Division of Vascular Surgery, Emory University School of Medicine, Atlanta, GA, Georgia.ORCID 0000-0002-7797-9291
Laura M HansenThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, Georgia.
Rudolph L GleasonThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, Georgia.
Tej K PanditaDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-1399-808X
Mandy L FordDepartment of Surgery and Emory Transplant Center, Emory University School of Medicine, Atlanta, GA, Georgia.
Clayton R HuntDepartment of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX, USA.
Craig M CoopersmithDepartment of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, GA, Georgia. cmcoop3@emory.edu.
Emory University · USGeorgia Institute of Technology · USWashington University in St. Louis · USHouston Methodist · US

Funding

Mechanisms of Intestinal Integrity in Sepsis and ShockR01GM072808 · NIGMS · WASHINGTON UNIVERSITY · PI COOPERSMITH, CRAIG M · 2005 to 2021
$5.1M
Critical Care Training ProgramT32GM095442 · NIGMS · EMORY UNIVERSITY · PI Craig M Coopersmith · 2011 to 2026
$4.7M
CHROMATIN MODIFYING FACTORS CONTROL RADIATION RESPONSE AND GENOMIC STABILITYR01CA129537 · NCI · WASHINGTON UNIVERSITY · PI PANDITA, TEJ K · 2008 to 2018
$3.3M
The Impact of Cancer on the Pathophysiology of SepsisR01GM104323 · NIGMS · EMORY UNIVERSITY · PI COOPERSMITH, CRAIG M, FORD, MANDY L · 2013 to 2021
$2.4M
Role of Heterochromatin protein 1 Beta in Genome Maintenance and OncogenesisR01GM109768 · NIGMS · METHODIST HOSPITAL RESEARCH INSTITUTE · PI PANDITA, TEJ K · 2014 to 2017
$1.2M
The Impact of Chronic Alcohol Abuse on the Pathophysiology of SepsisR01GM109779 · NIGMS · EMORY UNIVERSITY · PI COOPERSMITH, CRAIG M, FORD, MANDY L · 2014 to 2017
$1.2M
Targeting 2B4 Coinhibitory Signals During Sepsis-Induced Immune DysregulationR01GM113228 · NIGMS · EMORY UNIVERSITY · PI COOPERSMITH, CRAIG M, FORD, MANDY L · 2015 to 2018
$1.2M
Molecular Mechanism of Disturbed Flow in Arterial StiffeningK08HL119592 · NHLBI · EMORY UNIVERSITY · PI BREWSTER, LUKE PACKARD · 2014 to 2018
$690k
NCI NIH HHS R01 CA129537NHLBI NIH HHS K08 HL119592NIGMS NIH HHS R01 GM072808NIGMS NIH HHS R01 GM104323NIGMS NIH HHS R01 GM109768NIGMS NIH HHS R01 GM109779NIGMS NIH HHS R01 GM113228NIGMS NIH HHS T32 GM095442
6 · The paper itself

Abstract

In vitro studies have implicated the small heat shock protein HSPB1 in a range of physiological functions. However, its in vivo relevance is unclear as the phenotype of unstressed HSPB1

Indexed as

AnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDisease Models, AnimalGene Knockout TechniquesHeat-Shock ProteinsInterferon-gammaInterleukin-6MaleMiceMice, Inbred C57BLMolecular ChaperonesMortalityNeoplasm ProteinsPeritoneumSepsisHeat-Shock ProteinsHsbp1 protein, mouseInterferon-gammaInterleukin-6interleukin-6, mouseMolecular ChaperonesNeoplasm Proteins

Identifiers

PMID30131526
PMCPMC6104051
OpenAlexW2886841164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.