ArticleScientific reports2018
mRNA-specific translation regulation by a ribosome-associated ncRNA in Haloferax volcanii.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Archaeal RNA processing and regulation: expanding the functional landscape.Microbiology and molecular biology reviews : MMBR · 2025Review
- Investigation of the global translational response to oxidative stress in the model archaeonmSphere · 2025Article
- Review
- Specialized ribosomes: integrating new insights and current challenges.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- RiboReport - benchmarking tools for ribosome profiling-based identification of open reading frames in bacteria.Briefings in bioinformatics · 2022Article
- Ribosome-Associated ncRNAs (rancRNAs) Adjust Translation and Shape Proteomes.Non-coding RNA · 2022Review
- A small ribosome-associated ncRNA globally inhibits translation by restricting ribosome dynamics.RNA biology · 2021Article
- Post-transcriptional regulation of redox homeostasis by the small RNA SHOxi in haloarchaea.RNA biology · 2021Article
- Article
- Open Issues for Protein Function Assignment inGenes · 2021Article
- The role of micropeptides in biology.Cellular and molecular life sciences : CMLS · 2021Review
- Transcriptome-Wide Analysis of Stationary Phase Small ncRNAs inInternational journal of molecular sciences · 2021Article
- RNA antitoxin SprF1 binds ribosomes to attenuate translation and promote persister cell formation in Staphylococcus aureus.Nature microbiology · 2021Article
- Modulation of mammalian translation by a ribosome-associated tRNA half.RNA biology · 2020Article
- Ribosome profiling in archaea reveals leaderless translation, novel translational initiation sites, and ribosome pausing at single codon resolution.Nucleic acids research · 2020Article
- Regulatory Noncoding Small RNAs Are Diverse and Abundant in an Extremophilic Microbial Community.mSystems · 2020Article
- The Primary Antisense Transcriptome ofGenes · 2019Article
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Authors and funding
5 authors.
Funding
Abstract
Regulation of gene expression at the translational level allows rapid adaptation of cellular proteomes to quickly changing environmental conditions and is thus central for prokaryotic organisms. Small non-coding RNAs (sRNAs) have been reported to effectively orchestrate translation control in bacteria and archaea mainly by targeting mRNAs by partial base complementarity. Here we report an unprecedented mechanism how sRNAs are capable of modulating protein biosynthesis in the halophilic archaeon Haloferax volcanii. By analyzing the ribosome-associated ncRNAs (rancRNAs) under different stress conditions we identified an intergenic sRNA, termed rancRNA_s194, that is primarily expressed during exponential growth under all tested conditions. By interaction with the ribosome rancRNA_s194 inhibits peptide bond formation and protein synthesis in vitro but appears to target a specific mRNA in vivo. The respective knock-out strain shows a reduced lag phase in media containing xylose as sole carbon source and outcompetes the wildtype cells under these conditions. Mass spectrometry, polysome profiling and mRNA binding competition experiments suggest that rancRNA_s194 prevents the cstA mRNA from being efficiently translated by H. volcanii ribosomes. These findings enlarge the regulatory repertoire of archaeal sRNAs in modulating post-transcriptional gene expression.
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