Evidence map›Paper›PMID 30131496›Full record

ArticleNature communications2018

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism.

Nigel Turner, Xin Ying Lim, Hamish D Toop, Brenna Osborne, Amanda E Brandon, Elysha N Taylor, Corrine E Fiveash, Hemna Govindaraju, Jonathan D Teo, Holly P McEwen and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 137 citations in OpenAlex.

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  16. Structure of the yeast ceramide synthase.Nature structural & molecular biology · 2025
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 1 country.

Nigel TurnerSchool of Medical Sciences, UNSW Sydney, Sydney, 2052, NSW, Australia. n.turner@unsw.edu.au.
Xin Ying LimPrince of Wales Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, 2052, NSW, Australia.
Hamish D ToopSchool of Chemistry, UNSW Sydney, Sydney, 2052, NSW, Australia.ORCID http://orcid.org/0000-0003-4637-4764
Brenna OsborneSchool of Medical Sciences, UNSW Sydney, Sydney, 2052, NSW, Australia.ORCID http://orcid.org/0000-0002-0197-3010
Amanda E BrandonSydney Medical School, Charles Perkins Centre, University of Sydney, Sydney, 2006, NSW, Australia.
Elysha N TaylorSchool of Chemistry, UNSW Sydney, Sydney, 2052, NSW, Australia.
Corrine E FiveashSchool of Medical Sciences, UNSW Sydney, Sydney, 2052, NSW, Australia.
Hemna GovindarajuSchool of Medical Sciences, UNSW Sydney, Sydney, 2052, NSW, Australia.
Jonathan D TeoCentenary Institute, The University of Sydney, Sydney, 2006, NSW, Australia.
Holly P McEwenCentenary Institute, The University of Sydney, Sydney, 2006, NSW, Australia.
Timothy A CouttasCentenary Institute, The University of Sydney, Sydney, 2006, NSW, Australia.
Stephen M ButlerSchool of Chemistry, UNSW Sydney, Sydney, 2052, NSW, Australia.
Abhirup DasSchool of Medical Sciences, UNSW Sydney, Sydney, 2052, NSW, Australia.
Greg M KowalskiInstitute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Burwood, 3125, VIC, Australia.ORCID http://orcid.org/0000-0002-1599-017X
Clinton R BruceInstitute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Burwood, 3125, VIC, Australia.
Kyle L HoehnSchool of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, 2052, NSW, Australia.ORCID http://orcid.org/0000-0002-0214-3238
Thomas FathSchool of Medical Sciences, UNSW Sydney, Sydney, 2052, NSW, Australia.
Carsten Schmitz-PeifferGarvan Institute of Medical Research, Sydney, 2010, NSW, Australia.
Gregory J CooneySydney Medical School, Charles Perkins Centre, University of Sydney, Sydney, 2006, NSW, Australia.
Magdalene K MontgomerySchool of Medical Sciences, UNSW Sydney, Sydney, 2052, NSW, Australia.
Jonathan C MorrisSchool of Chemistry, UNSW Sydney, Sydney, 2052, NSW, Australia. jonathan.morris@unsw.edu.au.ORCID http://orcid.org/0000-0002-5109-9069
Anthony S DonCentenary Institute, The University of Sydney, Sydney, 2006, NSW, Australia. anthony.don@sydney.edu.au.
UNSW Sydney · AUThe University of Sydney · AUDeakin University · AUGarvan Institute of Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Specific forms of the lipid ceramide, synthesized by the ceramide synthase enzyme family, are believed to regulate metabolic physiology. Genetic mouse models have established C16 ceramide as a driver of insulin resistance in liver and adipose tissue. C18 ceramide, synthesized by ceramide synthase 1 (CerS1), is abundant in skeletal muscle and suggested to promote insulin resistance in humans. We herein describe the first isoform-specific ceramide synthase inhibitor, P053, which inhibits CerS1 with nanomolar potency. Lipidomic profiling shows that P053 is highly selective for CerS1. Daily P053 administration to mice fed a high-fat diet (HFD) increases fatty acid oxidation in skeletal muscle and impedes increases in muscle triglycerides and adiposity, but does not protect against HFD-induced insulin resistance. Our inhibitor therefore allowed us to define a role for CerS1 as an endogenous inhibitor of mitochondrial fatty acid oxidation in muscle and regulator of whole-body adiposity.

Indexed as

AnimalsCell RespirationDiet, High-FatEnzyme InhibitorsFatty AcidsHEK293 CellsHumansInhibitory Concentration 50Insulin ResistanceLipid MetabolismLiverMaleMice, Inbred C57BLMitochondriaMuscle, SkeletalOxidation-Reductiondihydroceramide desaturaseEnzyme InhibitorsFatty AcidsOxidoreductasesSphingolipids

Identifiers

PMID30131496
PMCPMC6104039
OpenAlexW2885871437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.