Trial reportProceedings of the National Academy of Sciences of the United States of America2018
Local field potentials of subthalamic nucleus contain electrophysiological footprints of motor subtypes of Parkinson's disease.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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Who cites it
35 citing papers in PubMed.
- Mapping of subthalamic nucleus using microelectrode recordings during deep brain stimulation.Scientific reports · 2020Trial
- EEG-based clustering shows distinct separation of chronic pain patients before spinal cord stimulation surgery.NeuroImage · 2026Article
- Localizing beta synchronous neurons in the STN using directional DBS recordings and patient-specific biophysical models.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Article
- The potential of utilizing Local Field Potential (LFP) in diagnosis and management of Parkinsonism's hallmark symptoms: a comprehensive review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- A Distributed Oscillatory Network Model of Parkinsonian Tremor: Integrating Basal Ganglia and Cerebello-Thalamic Circuits.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Review
- Local field potential biomarkers for adaptive deep brain stimulation in Parkinson's disease: A scoping review.Surgical neurology international · 2026Review
- Local Field Potentials in Movement Disorders: A Narrative Review.Stereotactic and functional neurosurgery · 2026Review
- Adaptive neuromodulation dialogues: navigating current challenges and emerging innovations in neuromodulation system development.Journal of neural engineering · 2025Review
- Beyond beta rhythms: subthalamic aperiodic broadband power scales with Parkinson's disease severity-a cross-sectional multicentre study.EBioMedicine · 2025Article
- Subthalamic Electrophysiological Mapping of Gait Initiation Dynamics and Freezing in Parkinson's Disease.Annals of neurology · 2025Article
- Dominant twin peaks: a novel conjecture for the pathophysiologic basis of tremor frequency and fluctuation time in Parkinson's disease.Frontiers in neuroscience · 2025Article
- Identifying genetic targets in clinical subtypes of Parkinson's disease for optimizing pharmacological treatment strategies.Signal transduction and targeted therapy · 2024Article
- Motor network gamma oscillations in chronic home recordings predict dyskinesia in Parkinson's disease.Brain : a journal of neurology · 2024Article
- Coupling between beta band and high frequency oscillations as a clinically useful biomarker for DBS.NPJ Parkinson's disease · 2024Article
- Wireless closed-loop deep brain stimulation using microelectrode array probes.Journal of Zhejiang University. Science. B · 2024Review
- Article
- Spectral Topography of the Subthalamic Nucleus to Inform Next-Generation Deep Brain Stimulation.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- β Oscillations of Dorsal STN as a Potential Biomarker in Parkinson's Disease Motor Subtypes: An Exploratory Study.Brain sciences · 2023Article
- The effect of deep brain stimulation in Parkinson's disease reflected in EEG microstates.NPJ Parkinson's disease · 2023Article
- Construction of semi-supervised spatial projections to identify the source of beta- and high frequency oscillations in Parkinson's disease.International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although motor subtypes of Parkinson's disease (PD), such as tremor dominant (TD) and postural instability and gait difficulty (PIGD), have been defined based on symptoms since the mid-1990s, no underlying neural correlates of these clinical subtypes have yet been identified. Very limited data exist regarding the electrophysiological abnormalities within the subthalamic nucleus (STN) that likely accompany the symptom severity or the phenotype of PD. Here, we show that activity in subbands of local field potentials (LFPs) recorded with multiple microelectrodes from subterritories of STN provide distinguishing neurophysiological information about the motor subtypes of PD. We studied 24 patients with PD and found distinct patterns between TD (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.