ArticlemBio2018
High-Throughput Screening Identifies Genes Required for
Open access · goldAbstract read
In one paragraph
Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 69 citations in OpenAlex.
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Corrections and comments
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Authors and funding
16 authors at 5 institutions in 2 countries.
Teresa R O'MearaDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Kwamaa DuahDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Cynthia X GuoDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Michelle E MaxsonProgram in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
Ryan G GaudetDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Kristy KoselnyDepartment of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Melanie WellingtonDivision of Pediatric Infectious Disease, University of Iowa, Iowa City, Iowa, USA.
Michael E PowersDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, USA.
Jessie MacAlpineDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Matthew J O'MearaDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, USA.
Amanda O VeriDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Sergio GrinsteinProgram in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
Suzanne M NobleDivision of Pediatric Infectious Disease, University of Iowa, Iowa City, Iowa, USA.
Damian KrysanDepartment of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Scott D Gray-OwenDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-1477-3616
Leah E CowenDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada leah.cowen@utoronto.ca.
University of Toronto · CAUniversity of California, San Francisco · USUniversity of Iowa · USUniversity of Rochester · USHospital for Sick Children · CA
Funding
Microbial Pathogenesis and Host DefenseT32AI060537 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joanne N. Engel · 2004 to 2026
$6.5MSystematic Analysis of Morphogenesis, Commensalism, and Virulence in a Leading Human Fungal PathogenR01AI127375 · NIAID · UNIVERSITY OF TORONTO · PI LEAH Elizabeth Cowen · 2017 to 2026
$5.3MGenetic screen for fungal triggers of the NLRP-3-inflammasone in macrophagesR21AI114837 · NIAID · UNIVERSITY OF ROCHESTER · PI KRYSAN, DAMIAN J, WELLINGTON, MELANIE · 2015 to 2016
$431kGlobal analysis of Hsp90 client proteins in Candida albicansF32AI115947 · NIAID · UNIVERSITY OF TORONTO · PI OMEARA, TERESA R. · 2015 to 2017
$168kA metabolic code for cell signaling and polypharmacology.F32GM114961 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI O'MEARA, MATTHEW J · 2016 to 2017
$115kUnderstanding C. albicans commensalism and virulence in multiple host environmental nichesF32AI131520 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POWERS, MICHAEL · 2018 to 2018
$39kCIHR FDN-154288CIHR PJT-148548CIHR PJT-153177CIHR PJT-153403NIAID NIH HHS F32 AI115947NIAID NIH HHS F32 AI131520NIAID NIH HHS R01 AI127375NIAID NIH HHS R21 AI114837NIAID NIH HHS T32 AI060537NIGMS NIH HHS F32 GM114961
Abstract
The innate immune system is the first line of defense against invasive fungal infections. As a consequence, many successful fungal pathogens have evolved elegant strategies to interact with host immune cells. For example,
Indexed as
Genes, FungalHost-Pathogen InteractionsPyroptosisAnimalsCandida albicansFemaleHigh-Throughput Screening AssaysImmune EvasionMacrophagesMiceMice, Inbred C57BLPhagocytosisCandidacell wall remodellingfunctional genomicsfungal morphogenesisfungal pathogenesishost-pathogen interactionpyroptosis
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.