ArticleG3 (Bethesda, Md.)2018
Imputation-Aware Tag SNP Selection To Improve Power for Large-Scale, Multi-ethnic Association Studies.
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In one paragraph
Article in G3 (Bethesda, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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35citing papers in PubMed, 1 pooled it
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries.The lancet. Diabetes & endocrinology · 2026Pooled it
- Novel type 1 diabetes polygenic scores improve identification of type 1 diabetes in diverse populations.medRxiv : the preprint server for health sciences · 2026Article
- Genetic predisposition to diabetes and risk of stroke in a Native Hawaiian population.Journal of diabetes and metabolic disorders · 2026Article
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- Integrative Mapping of Regulatory Variation in African American Hepatocytes Using Colocalization and MPRA: Toward Precision Drug Response.Research square · 2026Article
- Improving performance of polygenic risk scores for hypertension across two ancestry groups.PloS one · 2026Article
- Article
- Removing array-specific batch effects in GWAS mega-analyses by applying a two-step imputation workflow.Bioinformatics advances · 2026Article
- Improving type 2 diabetes polygenic risk scores by incorporating rare, low-frequency, and population-specific variants.medRxiv : the preprint server for health sciences · 2025Article
- Improving performance of polygenic risk scores for hypertension across two ancestry groups.medRxiv : the preprint server for health sciences · 2025Article
- Article
- NeuroBooster Array: A Genome-Wide Genotyping Platform to Study Neurological Disorders Across Diverse Populations.Movement disorders : official journal of the Movement Disorder Society · 2024Article
- Imputation accuracy across global human populations.American journal of human genetics · 2024Article
- Building a vertically integrated genomic learning health system: The biobank at the Colorado Center for Personalized Medicine.American journal of human genetics · 2024Article
- Review: Computational analysis of human skeletal remains in ancient DNA and forensic genetics.iScience · 2023Review
- NeuroBooster Array: A Genome-Wide Genotyping Platform to Study Neurological Disorders Across Diverse Populations.medRxiv : the preprint server for health sciences · 2023Article
- Cardiovascular Disease and Mortality in Black Women Carrying the Amyloidogenic V122I Transthyretin Gene Variant.JACC. Heart failure · 2023Article
- Including diverse and admixed populations in genetic epidemiology research.Genetic epidemiology · 2022Article
- Extent to which array genotyping and imputation with large reference panels approximate deep whole-genome sequencing.American journal of human genetics · 2022Article
- Type 1 diabetes in diverse ancestries and the use of genetic risk scores.The lancet. Diabetes & endocrinology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Genevieve L WojcikDepartment of Genetics, Stanford University School of Medicine, 365 Lasuen Street, Littlefield Center MC2069, Stanford, CA 94305.ORCID 0000-0001-7206-8088
Christian FuchsbergerDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109.
Daniel TaliunDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109.
Ryan WelchDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109.
Alicia R MartinDepartment of Genetics, Stanford University School of Medicine, 365 Lasuen Street, Littlefield Center MC2069, Stanford, CA 94305.ORCID 0000-0003-0241-3522
Suyash ShringarpureDepartment of Genetics, Stanford University School of Medicine, 365 Lasuen Street, Littlefield Center MC2069, Stanford, CA 94305.
Christopher S CarlsonFred Hutchinson Cancer Center, University of Washington, 1100 Fairview Ave. N., Seattle, WA 98109.
Goncalo AbecasisDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109.
Hyun Min KangDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109.
Carlos D BustamanteDepartment of Genetics, Stanford University School of Medicine, 365 Lasuen Street, Littlefield Center MC2069, Stanford, CA 94305.
Christopher R GignouxDepartment of Genetics, Stanford University School of Medicine, 365 Lasuen Street, Littlefield Center MC2069, Stanford, CA 94305 chris.gignoux@ucdenver.edu eimear.kenny@mssm.edu.ORCID 0000-0001-9728-6567
Eimear E KennyDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029 chris.gignoux@ucdenver.edu eimear.kenny@mssm.edu.ORCID 0000-0001-9198-759X
Funding
INSTITUTIONAL TRAINING GRANT IN GENOME SCIENCET32HG000044 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL P. SNYDER · 1995 to 2026
$32.2MGENETICS TRAINING PROGRAM FOR PHD CANDIDATEST32GM007790 · NIGMS · STANFORD UNIVERSITY · PI BRUNET, ANNE, KINGSLEY, DAVID M · 1985 to 2020
$12.8MIdentifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6MDESIGN AND ANALYSIS OF HUMAN GENE MAPPING STUDIESR01HG000376 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L · 1993 to 2016
$5.5MOptimizing imputation for diverse populations in a distributed frameworkU01HG009080 · NHGRI · STANFORD UNIVERSITY · PI KENNY, EIMEAR ELIZABETH · 2016 to 2020
$5.2MNHGRI PAGE Coordinating CenterU01HG007419 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI BUYSKE, STEVEN G, MATISE, TARA C. · 2013 to 2017
$3.7MDiverse ancestry biobank to map biomedical traits and elucidate health disparitieU01HG007417 · NHGRI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LOOS, RUTH JF · 2013 to 2017
$3.5MExonic variants and their relation to complex traits in minorities of the WHIU01HG007376 · NHGRI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L · 2013 to 2017
$3.2MDesign and Analysis of Human Gene Mapping StudiesR01HG009976 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L · 2018 to 2022
$2.5MTransforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9MCOMPUTATIONAL METHODS FOR PROTEOMIC ANALYSISK22HG000044 · NHGRI · UNIVERSITY OF UTAH · PI GIDDINGS, MORGAN CORINNE · 2000 to 2005
$1.3MNHGRI NIH HHS K22 HG000044NHGRI NIH HHS R01 HG000376NHGRI NIH HHS R01 HG009976NHGRI NIH HHS T32 HG000044NHGRI NIH HHS U01 HG007376NHGRI NIH HHS U01 HG007417NHGRI NIH HHS U01 HG007419NHGRI NIH HHS U01 HG009080NIDDK NIH HHS U01 DK062370NIGMS NIH HHS T32 GM007790NIH HHS S10 OD018522
Abstract
The emergence of very large cohorts in genomic research has facilitated a focus on genotype-imputation strategies to power rare variant association. These strategies have benefited from improvements in imputation methods and association tests, however little attention has been paid to ways in which array design can increase rare variant association power. Therefore, we developed a novel framework to select tag SNPs using the reference panel of 26 populations from Phase 3 of the 1000 Genomes Project. We evaluate tag SNP performance
Indexed as
Genetic Association StudiesGenetics, PopulationPolymorphism, Single NucleotideSelection, GeneticComputational BiologyDatabases, Nucleic AcidEthnicityGenome-Wide Association StudyHumansLinkage DisequilibriumModels, GeneticReproducibility of Resultsarray designGenomicsImputationStatistical Geneticstag SNPs
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.