Evidence map›Paper›PMID 30131246›Full record

Trial reportClinical breast cancer2018

Unifocal Invasive Lobular Carcinoma: Tumor Size Concordance Between Preoperative Ultrasound Imaging and Postoperative Pathology.

Gopal R Vijayaraghavan, Srinivasan Vedantham, Gabriela Santos-Nunez, Rebecca Hultman

Abstract readClinical Trial
In one paragraph

Trial report in Clinical breast cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Gopal R VijayaraghavanDepartment of Radiology, University of Massachusetts Medical School, Worcester, MA.
Srinivasan VedanthamDepartment of Medical Imaging, University of Arizona, Tucson, AZ. Electronic address: svedantham@radiology.arizona.edu.
Gabriela Santos-NunezDepartment of Radiology, University of Massachusetts Medical School, Worcester, MA.
Rebecca HultmanYork Hospital Breast Care, York, ME.
University of Massachusetts Chan Medical School · USBanner - University Medical Center Tucson · US

Funding

Reducing mastectomy rates in invasive lobular carcinoma by high-resolution 3D breast CTR01CA195512 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI VEDANTHAM, SRINIVASAN · 2015 to 2017
$757k
NCI NIH HHS R01 CA195512
6 · The paper itself

Abstract

backgroundWe systematically analyzed the extent of disease in unifocal invasive lobular carcinoma (ILC) using ultrasonography, with the histopathologic findings as the reference standard. PATIENTS AND

methodsIn the present single-institution retrospective study, 128 cases of ILC were identified during a 5-year period. After exclusions, the analyzed cohort included 66 cases. Ultrasound measurements of the tumor extent along 3 axes were obtained. The tumor size was determined as the largest extent among the 3 axes and the tumor volume by ellipsoidal approximation. Pathology review provided the tumor size and volume. Correlation and regression analyses of tumor size and volume from the ultrasound and pathologic examinations were performed. The tumor stage from the ultrasound and pathologic examinations were used for the concordance analyses.

resultsThe median and quartiles (Q1, Q3) of tumor size from ultrasonography and pathology were 12.5 mm (Q1, 9 mm; Q3, 19 mm) and 17 mm (Q1, 12 mm; Q3, 25 mm), respectively. The corresponding data for tumor volume were 0.52 cm

conclusionUltrasonography underestimates the tumor size and volume, with the underestimation increasing for larger tumors. Hence, the concordance rate in tumor size stage between ultrasonography and pathology is tumor size dependent, with the greatest concordance rate observed for pT1 tumors.

Indexed as

Postoperative CarePreoperative CareBreast NeoplasmsCarcinoma, LobularFemaleFollow-Up StudiesHumansMiddle AgedNeoplasm InvasivenessPrognosisRetrospective StudiesTumor BurdenUltrasonographyBreastCancerILCPathologic examinationUltrasound examination

Identifiers

PMID30131246
PMCPMC6283665
OpenAlexW2883374925

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.