Evidence map›Paper›PMID 30130819›Full record

ArticleAmerican journal of perinatology2019

Infants Born to Mothers with Clinical Chorioamnionitis: A Cross-Sectional Survey on the Use of Early-Onset Sepsis Risk Calculator and Prolonged Use of Antibiotics.

Marina Ayrapetyan, David Carola, Satyan Lakshminrusimha, Vineet Bhandari, Zubair H Aghai

Open access · greenAbstract read
In one paragraph

Article in American journal of perinatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Marina AyrapetyanDepartment of Pediatrics/Neonatology, Thomas Jefferson University/Nemours, Philadelphia, Pennsylvania.
David CarolaDepartment of Pediatrics/Neonatology, Thomas Jefferson University/Nemours, Philadelphia, Pennsylvania.
Satyan LakshminrusimhaDepartment of Pediatrics, University of California, Davis, California.
Vineet BhandariDepartment of Neonatology, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Zubair H AghaiDepartment of Pediatrics/Neonatology, Thomas Jefferson University/Nemours, Philadelphia, Pennsylvania.
Thomas Jefferson University · USDrexel University · USUniversity of California, Davis · US

Funding

Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI LEE M PACHTER · 2013 to 2026
$60.5M
Center for Pediatric Research Pilot ProgramP30GM114736 · NIGMS · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · PI SHAFFER, THOMAS H · 2015 to 2019
$5.1M
NIGMS NIH HHS P30 GM114736NIGMS NIH HHS U54 GM104941
6 · The paper itself

Abstract

objectiveTo evaluate variations in practice for the management of neonates born to mothers with clinical chorioamnionitis.

methodsThis was a prospective cross-sectional survey consisting of 10 multiple choice questionnaires distributed to 2,900 members of the Perinatal Section of American Academy of Pediatrics. Variations in responses were assessed and compared between the various groups.

resultsA total of 682 members (23.5%) completed the survey; 169 (24.8%) indicated that they use the neonatal early-onset sepsis (EOS) risk calculator for the management of neonates born to mothers with clinical chorioamnionitis. More respondents from the western region of United States and level III units are using the EOS risk calculator compared with the south and level II units. Approximately 44% of the respondents indicated that they will not stop antibiotics at 48 to 72 hours in asymptomatic neonates born to mothers with chorioamnionitis with negative blood culture if the complete blood count (CBC) and C-reactive protein (CRP) are abnormal.

conclusionA large number of practitioners are using the neonatal EOS risk calculator for neonates born to mothers with chorioamnionitis. Despite a clear guideline from the Committee on Fetus and Newborn, almost 44% will treat healthy-appearing neonates born to mothers with chorioamnionitis with a prolonged course of antibiotics solely for abnormal CBC or CRP.

Indexed as

ChorioamnionitisGuideline AdherenceRisk AssessmentAnti-Bacterial AgentsAntimicrobial StewardshipAsymptomatic InfectionsBlood Cell CountC-Reactive ProteinCross-Sectional StudiesFemaleHealth Care SurveysHumansInfant, NewbornNeonatal SepsisPractice Guidelines as TopicPregnancyAnti-Bacterial AgentsC-Reactive Protein

Identifiers

PMID30130819
PMCPMC8631007
OpenAlexW2888709133

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.