ArticleNeuroImage2018
Generic dynamic causal modelling: An illustrative application to Parkinson's disease.
Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Five Fristonian Formulae.Entropy (Basel, Switzerland) · 2025Article
- Cerebellar control over inter-regional excitatory/inhibitory dynamics discriminates execution from observation of an action.Cerebellum (London, England) · 2025Article
- Predictive modeling of evoked intracranial EEG response to medial temporal lobe stimulation in patients with epilepsy.Communications biology · 2024Article
- Multiscale modeling of neuronal dynamics in hippocampus CA1.Frontiers in computational neuroscience · 2024Article
- A multi-layer mean-field model of the cerebellum embedding microstructure and population-specific dynamics.PLoS computational biology · 2023Article
- Multi-modal and multi-model interrogation of large-scale functional brain networks.NeuroImage · 2023Article
- Connectivity alteration in thalamic nuclei and default mode network-related area in memory processes in mesial temporal lobe epilepsy using magnetoencephalography.Scientific reports · 2023Article
- Frequency dependent emotion differentiation and directional coupling in amygdala, orbitofrontal and medial prefrontal cortex network with intracranial recordings.Molecular psychiatry · 2023Article
- Subthalamic nucleus shows opposite functional connectivity pattern in Huntington's and Parkinson's disease.Brain communications · 2023Article
- Stimulating at the right time to recover network states in a model of the cortico-basal ganglia-thalamic circuit.PLoS computational biology · 2022Article
- A Novel Method to Assess Motor Cortex Connectivity and Event Related Desynchronization Based on Mass Models.Brain sciences · 2021Article
- Adiabatic dynamic causal modelling.NeuroImage · 2021Article
- Inference of brain networks with approximate Bayesian computation - assessing face validity with an example application in Parkinsonism.NeuroImage · 2021Article
- Cortical signatures of precision grip force control in children, adolescents, and adults.eLife · 2021Article
- Markov blankets in the brain.Neuroscience and biobehavioral reviews · 2021Review
- The Importance of Cerebellar Connectivity on Simulated Brain Dynamics.Frontiers in cellular neuroscience · 2020Article
- Dopaminergic modulation of motor network compensatory mechanisms in Parkinson's disease.Human brain mapping · 2019Article
- Thalamocortical dynamics underlying spontaneous transitions in beta power in Parkinsonism.NeuroImage · 2019Article
- The road ahead in clinical network neuroscience.Network neuroscience (Cambridge, Mass.) · 2019Review
- Deep Brain Stimulation Programming 2.0: Future Perspectives for Target Identification and Adaptive Closed Loop Stimulation.Frontiers in neurology · 2019Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
We present a technical development in the dynamic causal modelling of electrophysiological responses that combines qualitatively different neural mass models within a single network. This affords the option to couple various cortical and subcortical nodes that differ in their form and dynamics. Moreover, it enables users to implement new neural mass models in a straightforward and standardized way. This generic framework hence supports flexibility and facilitates the exploration of increasingly plausible models. We illustrate this by coupling a basal ganglia-thalamus model to a (previously validated) cortical model developed specifically for motor cortex. The ensuing DCM is used to infer pathways that contribute to the suppression of beta oscillations induced by dopaminergic medication in patients with Parkinson's disease. Experimental recordings were obtained from deep brain stimulation electrodes (implanted in the subthalamic nucleus) and simultaneous magnetoencephalography. In line with previous studies, our results indicate a reduction of synaptic efficacy within the circuit between the subthalamic nucleus and external pallidum, as well as reduced efficacy in connections of the hyperdirect and indirect pathway leading to this circuit. This work forms the foundation for a range of modelling studies of the synaptic mechanisms (and pathophysiology) underlying event-related potentials and cross-spectral densities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.