ArticleNeuroImage2018
Metastable neural dynamics in Alzheimer's disease are disrupted by lesions to the structural connectome.
Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Dynamic Functional Synchronization Profiles in Autism Differ by Spatial Scale and Along Hierarchical Cortical Gradients.Biological psychiatry global open science · 2026Article
- Cortical synchrony is reduced in Alzheimer's disease and relates to arousal state.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Excitation-inhibition homeostasis in Alzheimer's disease: a selective multiscale review of mechanisms, sex differences, and therapeutic opportunities.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Stable individualized brain computing model informed by spatiotemporal co-activity patterns.PLoS computational biology · 2025Article
- Development of brain metastable dynamics during the equivalent of the third gestational trimester.Developmental cognitive neuroscience · 2025Review
- Altered intrinsic ignition dynamics linked to Amyloid-bioRxiv : the preprint server for biology · 2025Article
- Metastability demystified - the foundational past, the pragmatic present and the promising future.Nature reviews. Neuroscience · 2025Review
- Metastable dynamics emerge from local excitatory-inhibitory homeostasis in the cortex at rest.Network neuroscience (Cambridge, Mass.) · 2025Article
- Inter-brain synchrony to delineate the social impairment in autism spectrum disorder: a systematic review on hyperscanning studies.Psychoradiology · 2025Review
- Individualized mouse brain network models produce asymmetric patterns of functional connectivity after simulated traumatic injury.Network neuroscience (Cambridge, Mass.) · 2025Article
- A scoping review of mathematical models covering Alzheimer's disease progression.Frontiers in neuroinformatics · 2024Article
- Constructing representative group networks from tractography: lessons from a dynamical approach.Frontiers in network physiology · 2024Article
- Genetic basis of anatomical asymmetry and aberrant dynamic functional networks in Alzheimer's disease.Brain communications · 2024Article
- Spatial organisation of the mesoscale connectome: A feature influencing synchrony and metastability of network dynamics.PLoS computational biology · 2023Article
- Alzheimer's Disease: Insights from Large-Scale Brain Dynamics Models.Brain sciences · 2023Review
- Genuine high-order interactions in brain networks and neurodegeneration.Neurobiology of disease · 2022Article
- Evaluating the Alterations Induced by Virtual Reality in Cerebral Small-World Networks Using Graph Theory Analysis with Electroencephalography.Brain sciences · 2022Article
- Dopamine depletion and subcortical dysfunction disrupt cortical synchronization and metastability affecting cognitive function in Parkinson's disease.Human brain mapping · 2022Article
- Connectomic analysis of Alzheimer's disease using percolation theory.Network neuroscience (Cambridge, Mass.) · 2022Article
- Impaired Brain Information Transmission Efficiency and Flexibility in Parkinson's Disease and Rapid Eye Movement Sleep Behavior Disorder: Evidence from Functional Connectivity and Functional Dynamics.Parkinson's disease · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Current theory suggests brain regions interact to reconcile the competing demands of integration and segregation by leveraging metastable dynamics. An emerging consensus recognises the importance of metastability in healthy neural dynamics where the transition between network states over time is dependent upon the structural connectivity between brain regions. In Alzheimer's disease (AD) - the most common form of dementia - these couplings are progressively weakened, metastability of neural dynamics are reduced and cognitive ability is impaired. Accordingly, we use a joint empirical and computational approach to reveal how behaviourally relevant changes in neural metastability are contingent on the structural integrity of the anatomical connectome. We estimate the metastability of fMRI BOLD signal in subjects from across the AD spectrum and in healthy controls and demonstrate the dissociable effects of structural disconnection on synchrony versus metastability. In addition, we reveal the critical role of metastability in general cognition by demonstrating the link between an individuals cognitive performance and their metastable neural dynamic. Finally, using whole-brain computer modelling, we demonstrate how a healthy neural dynamic is conditioned upon the topological integrity of the structural connectome. Overall, the results of our joint computational and empirical analysis suggest an important causal relationship between metastable neural dynamics, cognition, and the structural efficiency of the anatomical connectome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.