Evidence map›Paper›PMID 30130555›Full record

ArticleToxicology and applied pharmacology2018

Sodium arsenite exposure inhibits histone acetyltransferase p300 for attenuating H3K27ac at enhancers in mouse embryonic fibroblast cells.

Yan Zhu, Yanqiang Li, Dan Lou, Yang Gao, Jing Yu, Dehui Kong, Qiang Zhang, Yankai Jia, Haimou Zhang, Zhibin Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology and applied pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Epigenomic reprogramming in iAs-mediated carcinogenesis.Advances in pharmacology (San Diego, Calif.) · 2023
    Article
  7. Review
  8. Article
  9. Review
  10. Epigenetic biomarkers and preterm birth.Environmental epigenetics · 2020
    Review
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Yan ZhuLaboratory of Human Environmental Epigenome, Department of Environmental Health & Engineering, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, USA.
Yanqiang LiLaboratory of Human Environmental Epigenome, Department of Environmental Health & Engineering, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, USA.
Dan LouLaboratory of Human Environmental Epigenome, Department of Environmental Health & Engineering, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, USA.
Yang GaoLaboratory of Human Environmental Epigenome, Department of Environmental Health & Engineering, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, USA.
Jing YuLaboratory of Human Environmental Epigenome, Department of Environmental Health & Engineering, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, USA.
Dehui KongLaboratory of Human Environmental Epigenome, Department of Environmental Health & Engineering, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, USA; Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, College of Life Sciences, Hubei University, 368 Youyi Avenue, Wuchang District, Wuhan, Hubei Province 430062, China.
Qiang ZhangLaboratory of Human Environmental Epigenome, Department of Environmental Health & Engineering, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, USA; Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, No. 22 Qixiangtai Road, Tianjin 300070, China.
Yankai JiaGENEWIZ Suzhou, 218 Xinghu Road, Suzhou Industrial Park, Suzhou 215123, China. Electronic address: yankai.jia@genewiz.com.
Haimou ZhangHubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, College of Life Sciences, Hubei University, 368 Youyi Avenue, Wuchang District, Wuhan, Hubei Province 430062, China. Electronic address: haimou@hubu.edu.cn.
Zhibin WangLaboratory of Human Environmental Epigenome, Department of Environmental Health & Engineering, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, USA; Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, College of Life Sciences, Hubei University, 368 Youyi Avenue, Wuchang District, Wuhan, Hubei Province 430062, China; Fengxian Central Hospital, 9588 Nanfeng Hwy, Fengxian District, Shanghai 201406, China. Electronic address: zwang47@jhu.edu.
Johns Hopkins University · USHubei University · CNSuzhou Research Institute · CNTianjin Medical University · CN

Funding

Investigating Effect of Air pollution and Host Defenses in SARS-CoV2 infectionU01ES026721 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI BISWAL, SHYAM, RAJAGOPALAN, SANJAY · 2016 to 2020
$3.8M
Exposure-altered gene expression in five candidate imprinted loci for adult diseaseR01ES025761 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI WANG, ZHIBIN · 2016 to 2020
$1.5M
Window of Susceptibility for Epigenetic Programming and Asthma PathogenesisR21ES028351 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI TANG, WAN-YEE, WANG, ZHIBIN · 2017 to 2018
$450k
NIEHS NIH HHS R01 ES025761NIEHS NIH HHS R21 ES028351NIEHS NIH HHS U01 ES026721
6 · The paper itself

Abstract

Both epidemiological investigations and animal studies have linked arsenic-contaminated water to cancers, including skin, liver and lung cancers. Besides genotoxicity, arsenic exposure-related pathogenesis of disease is widely considered through epigenetic mechanisms; however, the underlying mechanism remains to be determined. Herein we explore the initial epigenetic changes via acute sodium arsenite (As) exposures of mouse embryonic fibroblast (MEF) cells and histone H3K79 methyltransferase Dot1L knockout (Dot1L

Indexed as

AnimalsArsenitesCell LineFibroblastsGene Expression RegulationHistonesKruppel-Like Factor 4Micep300-CBP-Associated Factorp300-CBP Transcription FactorsRNA, MessengerSodium CompoundsArsenitesHistonesKLF4 protein, humanKlf4 protein, mouseKruppel-Like Factor 4p300-CBP-Associated Factorp300-CBP Transcription FactorsRNA, Messengersodium arseniteSodium CompoundsCancersEnhancersH3K27acHistone acetyltransferase p300Sodium arsenite

Identifiers

PMID30130555
PMCPMC6526104
OpenAlexW2885233836

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.