Evidence map›Paper›PMID 30130434›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Aging of the immune system causes reductions in muscle stem cell populations, promotes their shift to a fibrogenic phenotype, and modulates sarcopenia.

Ying Wang, Michelle Wehling-Henricks, Steven S Welc, Allison L Fisher, Qun Zuo, James G Tidball

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.

  1. Pooled it
  2. Neuromuscular electrical stimulation and protein during bed rest increases CD11bApplied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2020
    Trial
  3. Review
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  5. Article
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  8. Review
  9. Article
  10. Review
  11. Molecular Framework of the Onset and Progression of Skeletal Muscle Aging.International journal of molecular sciences · 2025
    Review
  12. Article
  13. The systemic costs of hematopoietic stem cell aging.Development (Cambridge, England) · 2025
    Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ying WangMolecular, Cellular, and Integrative Physiology Program, University of California, Los Angeles, Los Angeles, California, USA.
Michelle Wehling-HenricksDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, USA.
Steven S WelcDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, USA.
Allison L FisherMolecular, Cellular, and Integrative Physiology Program, University of California, Los Angeles, Los Angeles, California, USA.
Qun ZuoSchool of Kinesiology, Shanghai University of Sport, Shanghai, China.
James G TidballMolecular, Cellular, and Integrative Physiology Program, University of California, Los Angeles, Los Angeles, California, USA.
University of California, Los Angeles · USShanghai University of Sport · CN

Funding

Training in Molecular, Cellular &Integrative PhysiologyT32GM065823 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TIDBALL, JAMES G · 2003 to 2017
$2.1M
Regulation of sarcopenia and muscle dysfunction by nitric oxideR01AR054451 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TIDBALL, JAMES G · 2007 to 2011
$1.8M
Functions of myelomonocytic lineage cells in aging muscleR01AG041147 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TIDBALL, JAMES G · 2011 to 2015
$1.7M
NIAMS NIH HHS R01 AR054451NIA NIH HHS R01 AG041147NIGMS NIH HHS T32 GM065823
6 · The paper itself

Abstract

Aging is associated with diminished muscle mass, reductions in muscle stem cell functions, and increased muscle fibrosis. The immune system, especially macrophages, can have important roles in modulating muscle growth and regeneration, suggesting that the immune system may also have significant influences on muscle aging. Moreover, the immune system experiences changes in function during senescence, suggesting that regulatory interaction between muscle cells and the immune system may also change during aging. In this study, we performed bone marrow transplantations between age-mismatched donor and recipient mice to test the influence of the age of the immune system on muscle aging. Transplantation of young bone marrow cells into old recipients prevented sarcopenia and prevented age-related change in muscle fiber phenotype. Transplantation of old bone marrow cells into young animals reduced satellite cell numbers and promoted satellite cells to switch toward a fibrogenic phenotype. We also demonstrated that conditioned media from young, but not old, bone marrow cells promoted myoblast proliferation in vitro, and we found that factors released by young bone marrow cells were more supportive of myotube differentiation in vitro. Together, our results demonstrate that aging of bone marrow cells promotes the age-related reduction of satellite cell number and function and contributes to sarcopenia.-Wang, Y., Wehling-Henricks, M., Welc, S. S., Fisher, A. L., Zuo, Q., Tidball, J. G. Aging of the immune system causes reductions in muscle stem cell populations, promotes their shift to a fibrogenic phenotype, and modulates sarcopenia.

Indexed as

AgingAnimalsBiomarkersBone Marrow CellsCell DifferentiationCell ProliferationCellular SenescenceFemaleFibrosisHematopoietic Stem Cell TransplantationImmune SystemMacrophagesMaleMiceMice, Inbred C57BLMuscle Fibers, SkeletalBiomarkersbone marrow transplantationmacrophagemuscle fibrosissatellite cellskeletal muscle

Identifiers

PMID30130434
PMCPMC6355087
OpenAlexW2888191704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.