ArticlePLoS computational biology2018
Domes and cones: Adhesion-induced fission of membranes by ESCRT proteins.
Article in PLoS computational biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Dynamics of upstream ESCRT organization at the HIV-1 budding site.Biophysical journal · 2023Article
- Stepwise remodeling and subcompartment formation in individual vesicles by three ESCRT-III proteins.iScience · 2023Article
- Snf7 spirals sense and alter membrane curvature.Nature communications · 2022Article
- Protein crowding mediates membrane remodeling in upstream ESCRT-induced formation of intraluminal vesicles.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The ESCRTs - converging on mechanism.Journal of cell science · 2020Review
- Biophysical forces in membrane bending and traffic.Current opinion in cell biology · 2020Review
- Molecular Simulation of Mechanical Properties and Membrane Activities of the ESCRT-III Complexes.Biophysical journal · 2020Article
- Changes in ESCRT-III filament geometry drive membrane remodelling and fission in silico.BMC biology · 2019Article
- In Vitro Membrane Remodeling by ESCRT is Regulated by Negative Feedback from Membrane Tension.iScience · 2019Article
- Modeling Membrane Curvature Generation due to Membrane⁻Protein Interactions.Biomolecules · 2018Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ESCRT proteins participate in the fission step of exocytic membrane budding, by assisting in the closure and scission of the membrane neck that connects the nascent bud to the plasma membrane. However, the precise mechanism by which the proteins achieve this so-called reverse-topology membrane scission remains to be elucidated. One mechanism is described by the dome model, which postulates that ESCRT-III proteins assemble in the shape of a hemispherical dome at the location of the neck, and guide the closure of this neck via membrane-protein adhesion. A different mechanism is described by the flattening cone model, in which the ESCRT-III complex first assembles at the neck in the shape of a cone, which then flattens leading to neck closure. Here, we use the theoretical framework of curvature elasticity and membrane-protein adhesion to quantitatively describe and compare both mechanisms. This comparison shows that the minimal adhesive strength of the membrane-protein interactions required for scission is much lower for cones than for domes, and that the geometric constraints on the shape of the assembly required to induce scission are more stringent for domes than for cones. Finally, we compute for the first time the adhesion-induced constriction forces exerted by the ESCRT assemblies onto the membrane necks. These forces are higher for cones and of the order of 100 pN.
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