Evidence map›Paper›PMID 30129982›Full record

ArticleJournal of neuroendocrinology2018

High salt loading increases brain derived neurotrophic factor in supraoptic vasopressin neurones.

Kirthikaa Balapattabi, Joel T Little, George E Farmer, J Thomas Cunningham

Open access · greenAbstract read
In one paragraph

Article in Journal of neuroendocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Norepinephrine innervation of the supraoptic nucleus contributes to increased copeptin and dilutional hyponatremia in male rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
  5. Article
  6. Review
  7. Observational
  8. Article
  9. The Role of Astrocytes in the Modulation ofKInternational journal of molecular sciences · 2020
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kirthikaa BalapattabiDepartment of Physiology and Anatomy, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas.
Joel T LittleDepartment of Physiology and Anatomy, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas.
George E FarmerDepartment of Physiology and Anatomy, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas.
J Thomas CunninghamDepartment of Physiology and Anatomy, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas.ORCID 0000-0001-8859-9481
University of North Texas · US

Funding

Neural Regulation of Vasopressin Release in a Model of Dilutional HyponatremiaR01HL142341 · NHLBI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI CUNNINGHAM, J THOMAS · 2018 to 2021
$2.2M
Homeostatic Regulation of Supraoptic Neurons: Role of BDNFR01HL119458 · NHLBI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI CUNNINGHAM, J THOMAS · 2014 to 2017
$1.5M
NHLBI NIH HHS R01 HL119458NHLBI NIH HHS R01 HL142341
6 · The paper itself

Abstract

High salt loading (SL) is associated with inappropriate arginine vasopressin (AVP) release and increased mean arterial pressure. Previous work has shown that chronic high salt intake impairs baroreceptor inhibition of rat AVP neurones through brain-derived neurotrophic factor (BDNF) dependent activation of tyrosine receptor kinase B (TrkB) and down-regulation of K+/Cl- co-transporter KCC2. This mechanism diminishes the GABA

Indexed as

AnimalsArginine VasopressinArterial PressureBrain-Derived Neurotrophic FactorEatingGene ExpressionHeart RateMaleNeuronsRats, Sprague-DawleyReceptor, trkBSodiumSodium ChlorideSupraoptic NucleusArginine VasopressinBdnf protein, ratBrain-Derived Neurotrophic FactorNtrk2 protein, ratReceptor, trkBSodiumSodium ChlorideBDNFsalt loading and MNCsSONvasopressin

Identifiers

PMID30129982
PMCPMC6645701
OpenAlexW2806491597

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.