Evidence map›Paper›PMID 30129283›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2019

mTORC2 deficiency in cutaneous dendritic cells potentiates CD8

Alicia R Watson, Helong Dai, Julio A Diaz-Perez, Meaghan E Killeen, Alicia R Mathers, Angus W Thomson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. The role of mTORC2/RICTOR in immune cells and inflammatory diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  2. Best practices in mouse models of skin transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Review
  3. Article
  4. The "other" mTOR complex: New insights into mTORC2 immunobiology and their implications.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Alicia R WatsonDepartment of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Helong DaiDepartment of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Julio A Diaz-PerezDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Meaghan E KilleenDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Alicia R MathersDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Angus W ThomsonDepartment of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
University of Pittsburgh · USSecond Xiangya Hospital of Central South University · CN

Funding

Interdisciplinary Training in Transplantation BiologyT32AI074490 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Angus W Thomson · 2007 to 2026
$4.2M
Regulation of Liver DC Function and Transplant ToleranceR01AI118777 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THOMSON, ANGUS W · 2017 to 2021
$2.3M
P2X7R Signaling in Psoriasis PathogenesisR01AR067746 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MATHERS, ALICIA R · 2015 to 2019
$1.7M
Dendritic Cells, Rapamycin and Transplant ToleranceR01AI067541 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THOMSON, ANGUS W · 2007 to 2010
$1.7M
NIAID NIH HHS R01 AI067541NIAID NIH HHS R01 AI118777NIAID NIH HHS T32 AI074490NIAMS NIH HHS R01 AR067746
6 · The paper itself

Abstract

Mechanistic target of rapamycin (mTOR) complex (mTORC)1 and mTORC2 regulate the differentiation and function of immune cells. While inhibition of mTORC1 antagonizes dendritic cell (DC) differentiation and suppresses graft rejection, the role of mTORC2 in DCs in determining host responses to transplanted tissue remains undefined. Using a mouse model in which mTORC2 was deleted specifically in CD11c

Indexed as

AnimalsCD8-Positive T-LymphocytesDendritic CellsFemaleGraft RejectionGraft SurvivalLymphocyte ActivationMaleMechanistic Target of Rapamycin Complex 2MiceMice, Inbred C57BLMice, KnockoutSkinSkin TransplantationMechanistic Target of Rapamycin Complex 2antigen presentation/recognitionbasic (laboratory) research/sciencecellular biologydendritic celldermatologyimmunobiologyimmunosuppressant - mechanistic target of rapamycin (mTOR)

Identifiers

PMID30129283
PMCPMC6384165
OpenAlexW2888339171

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.