Evidence map›Paper›PMID 30129105›Full record

ArticleProteomics2018

Phospho-Proteomic Analysis of Cardiac Dyssynchrony and Resynchronization Therapy.

Marisa J Stachowski, Ronald J Holewinski, Eric Grote, Vidya Venkatraman, Jennifer E Van Eyk, Jonathan A Kirk

Abstract read
In one paragraph

Article in Proteomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Proteomics of the heart.Physiological reviews · 2024
    Review
  3. Article
  4. Inflammation and Heart Failure: Searching for the Enemy-Reaching the Entelechy.Journal of cardiovascular development and disease · 2023
    Review
  5. Review
  6. Article
  7. PINE: An Automation Tool to Extract and Visualize Protein-Centric Functional Networks.Journal of the American Society for Mass Spectrometry · 2020
    Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Marisa J StachowskiDepartment of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Ronald J HolewinskiAdvanced Clinical Biosystems Research Institute, Heart Institute and Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, 90048, USA.
Eric GroteDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Vidya VenkatramanAdvanced Clinical Biosystems Research Institute, Heart Institute and Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, 90048, USA.
Jennifer E Van EykAdvanced Clinical Biosystems Research Institute, Heart Institute and Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, 90048, USA.
Jonathan A KirkDepartment of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.ORCID 0000-0002-5192-2860
Cedars-Sinai Medical Center · USLoyola University Chicago · USJohns Hopkins University · US

Funding

Pathobiology of Cardiac Dyssynchrony &ResynchronizationP01HL077180 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI VAN EYK, JENNIFER E · 2004 to 2014
$22.8M
Genomic and Proteomic Architecture of AtherosclerosisR01HL111362 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HERRINGTON, DAVID MCLEOD · 2012 to 2021
$17.2M
GSK-3β Localizes to the Myofilament and Modifies its Function in Ischemic CardiomyopathyR01HL136737 · NHLBI · UNIVERSITY OF CHICAGO · PI JONATHAN A KIRK · 2017 to 2026
$4.5M
SOLID STATE STUDIES OF PHYSIOLOGICALLY IMPORTANT MOLECULESZ01HL001005 · NHLBI · HEART, LUNG, AND BLOOD INSTITUTE · PI SILVERTON, J V · 1985 to 1995
–
American Heart Association-American Stroke Association 14SDG20380148NHLBI NIH HHS HHSN268201000032CNHLBI NIH HHS NHLBI-HV-10-05(2)NHLBI NIH HHS P01 HL077180NHLBI NIH HHS P01-HL077180NHLBI NIH HHS R01 HL111362NHLBI NIH HHS R01 HL136737NHLBI NIH HHS R01-HL136737
6 · The paper itself

Abstract

Cardiac dyssynchrony arises from conduction abnormalities during heart failure and worsens morbidity and mortality. Cardiac resynchronization therapy (CRT) re-coordinates contraction using bi-ventricular pacing, but the cellular and molecular mechanisms involved remain largely unknown. The aim is to determine how dyssynchronous heart failure (HF

Indexed as

AnimalsBiomarkersCardiac Resynchronization TherapyDogsHeartHeart FailurePhosphoproteinsPhosphorylationProteomeSignal TransductionTandem Mass SpectrometryTreatment OutcomeBiomarkersPhosphoproteinsProteomeCK2dyssynchronyheart failurephosphorylation

Identifiers

PMID30129105
PMCPMC6417799
OpenAlexW2888205833

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.