ArticleNeurogastroenterology and motility2019
High-resolution optical mapping of gastric slow wave propagation.
Article in Neurogastroenterology and motility, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Optical Mapping of Pacing-Elicited Slow Waves in the Swine Stomach: Role of Virtual Electrodes.Neurogastroenterology and motility · 2026Article
- Simultaneous optical imaging of gastric slow waves and contractions in the in vivo porcine stomach.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Optimization of pacing parameters to entrain slow wave activity in the pig jejunum.Scientific reports · 2024Article
- Optical mapping and optogenetics in cardiac electrophysiology research and therapy: a state-of-the-art review.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Review
- Paralysis by analysis: Overcoming cardiac contraction with computer vision.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- High-resolution in vivo monophasic gastric slow waves to quantify activation and recovery profiles.Neurogastroenterology and motility · 2022Article
- Relationship Between Intestinal Slow-waves, Spike-bursts, and Motility, as Defined Through High-resolution Electrical and Video Mapping.Journal of neurogastroenterology and motility · 2022Article
- Real-Time Optical Mapping of Contracting Cardiac Tissues With GPU-Accelerated Numerical Motion Tracking.Frontiers in cardiovascular medicine · 2022Article
- Enlightening the frontiers of neurogastroenterology through optogenetics.American journal of physiology. Gastrointestinal and liver physiology · 2020Review
- Optical mapping of electromechanics in intact organs.Experimental biology and medicine (Maywood, N.J.) · 2020Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
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Abstract
backgroundImproved understanding of the details of gastric slow wave propagation could potentially inform new diagnosis and treatment options for stomach motility disorders. Optical mapping has been used extensively in cardiac electrophysiology. Although optical mapping has a number of advantages relative to electrical mapping, optical signals are highly sensitive to motion artifact. We recently introduced a novel cardiac optical mapping method that corrects motion artifact and enables optical mapping to be performed in beating hearts. Here, we reengineer the method as an experimental tool to map gastric slow waves.
methodsThe method was developed and tested in 12 domestic farm pigs. Stomachs were exposed by laparotomy and stained with the voltage-sensitive fluorescence dye di-4-ANEPPS through a catheter placed in the gastroepiploic artery. Fiducial markers for motion tracking were attached to the serosa. The dye was excited by 450 or 505 nm light on alternate frames of an imaging camera running at 300 Hz. Emitted fluorescence was imaged between 607 and 695 nm. The optical slow wave signal was reconstructed using a combination of motion tracking and excitation ratiometry to suppress motion artifact. Optical slow wave signals were compared with simultaneously recorded bipolar electrograms and suction electrode signals, which approximate membrane potential. KEY
resultsThe morphology of optical slow waves was consistent with previously published microelectrode recordings and simultaneously recorded suction electrode signals. The timing of the optical slow wave signals was consistent with the bipolar electrograms. CONCLUSIONS AND INFERENCES: Optical mapping of slow wave propagation in the stomach is feasible.
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