Evidence map›Paper›PMID 30128955›Full record

ArticleWiener klinische Wochenschrift2018

Non-vitamin K antagonist oral anticoagulants in patients with an increased risk of bleeding.

Thomas Gremmel, Alexander Niessner, Hans Domanovits, Martin Frossard, Gürkan Sengölge, Barbara Steinlechner, Thomas Sycha, Michael Wolzt, Ingrid Pabinger

Erratum issuedAbstract read
In one paragraph

Article in Wiener klinische Wochenschrift, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Thomas GremmelDepartment of Internal Medicine II, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. thomas.gremmel@meduniwien.ac.at.ORCID http://orcid.org/0000-0001-9554-7292
Alexander NiessnerDepartment of Internal Medicine II, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. alexander.niessner@meduniwien.ac.at.
Hans DomanovitsDepartment of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
Martin FrossardDepartment of Trauma Surgery, Medical University of Vienna, Vienna, Austria.
Gürkan SengölgeDepartment of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Barbara SteinlechnerDepartment of Anesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria.
Thomas SychaDepartment of Neurology, Medical University of Vienna, Vienna, Austria.
Michael WolztDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Ingrid PabingerDepartment of Internal Medicine I, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. ingrid.pabinger@meduniwien.ac.at.

Funding

Bayer unrestricted grantBoehringer Ingelheim unrestricted grant
6 · The paper itself

Abstract

The non-vitamin K antagonist oral anticoagulants (NOACs) have considerably changed clinical practice and are increasingly being used as an alternative to vitamin K antagonists (VKAs) for 3 main reasons: 1) an improved benefit-risk ratio (in particular lower rates of intracranial bleeding), 2) a more predictable effect without the need for routine monitoring, and 3) fewer food and drug interactions compared with VKAs. Currently, there are four NOACs available: the factor Xa inhibitors apixaban, edoxaban, and rivaroxaban, and the thrombin inhibitor dabigatran. This consensus paper reviews the properties and usage of NOACs in a number of high-risk patient populations, such as patients with chronic kidney disease, patients ≥80 years of age and others and provides guidance for the use of NOACs in patients at risk of bleeding.

Indexed as

StrokeAdministration, OralAged, 80 and overAnticoagulantsAtrial FibrillationDabigatranHemorrhageHumansRivaroxabanAnticoagulantsDabigatranRivaroxabanConsensusDabigatranDOACsFactor Xa inhibitorsNOACs

Identifiers

PMID30128955
PMCPMC6290726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.