Evidence map›Paper›PMID 30128934›Full record

ArticleJournal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology2018

Clinical and radiographic comparison of a single LP-PRP injection, a single hyaluronic acid injection and daily NSAID administration with a 52-week follow-up: a randomized controlled trial.

David Buendía-López, Manuel Medina-Quirós, Miguel Ángel Fernández-Villacañas Marín

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07016672 (Efficacy of Therapy With Intra-articular Injections of PRP Compared With Therapy With Intra-articular Injections of HA, in Patients With Grade III or IV GONArthrosis), which is not on this map. Cited by 81 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 18 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07016672 narecruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Therapy With Intra-articular Injections of PRP Compared With Therapy With Intra-articular Injections of HA, in Patients With Grade III or IV GONArthrosis: a Prospective Randomized Open-label Study

TypeinterventionalSponsorCentre Hospitalier Intercommunal de Toulon La Seyne sur MerRan2025 to 2028Enrolled150ConditionsKnee OsteoarthritisArmsintra-articular injection of HA, intra-articular injection of PRP
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 18 syntheses or guidelines pooled it, 145 citations in OpenAlex.

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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

David Buendía-LópezHospital Caravaca de la Cruz, Avenida Miguel Espinosa, 1, Caravaca de la Cruz, 30400, Murcia, Spain. david_buendia78@hotmail.com.
Manuel Medina-QuirósHospital Virgen de la Arrixaca, Carretera Madrid-Cartagena, El Palmar, 30120, Murcia, Spain.
Miguel Ángel Fernández-Villacañas MarínHuman Anatomy Department and Psychobiology, Murcia University, Campus de Espinardo, 30100, Murcia, Spain.
Hospital Universitario Virgen de la Arrixaca · ESUniversidad de Murcia · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKnee osteoarthritis (OA) is a disease with a high prevalence in the adult population. Nonsteroidal anti-inflammatory drugs (NSAID) or intra-articular injections [hyaluronic acid (HA) or platelet-rich plasma (PRP)] can provide clinical benefit. Magnetic resonance imaging (MRI) has proven to be useful for the evaluation of cartilage volume and thickness in knee osteoarthritis. The purpose of this study was to evaluate the benefit provided by PRP injection in comparison with hyaluronic acid and NSAID in knee OA patients and to compare the radiographic evolution at the 52-week follow-up.

methodsOne hundred and six patients were enrolled and randomized according to the Spanish Rheumatology Society knee osteoarthritis diagnosis criteria. Ninety-eight patients completed the study (33 received NSAID treatment, 32 a single hyaluronic acid injection and 33 a single PRP injection). Patients were prospectively evaluated at baseline, 26 and 52 weeks using the Western Ontario McMaster Universities osteoarthritis index (WOMAC) and the visual analogue scale (VAS), and at baseline and 52 weeks with X-ray and MRI.

resultsA 20% decrease in WOMAC pain and increase in physical function was found in 30 and 24%, respectively, of those patients who received PRP treatment, at the 52-week follow-up. WOMAC pain and VAS improved in the hyaluronic acid and NSAID groups. However, better results were obtained in the PRP group compared to hyaluronic acid and NSAIDs (P < 0.05). No differences in Kellgren-Lawrence or cartilage thickness progression were found.

conclusionsLeukocyte-poor platelet-rich plasma (LP-PRP) injections are better in terms of clinical improvement with respect to HA injections or oral NSAID treatment in knee osteoarthritis patients at the 52-week follow-up. Moreover, a single LP-PRP injection is effective. However, LP-PRP has no influence on cartilage progression. LEVEL OF EVIDENCE: Level II.

Indexed as

Platelet-Rich PlasmaAnti-Inflammatory Agents, Non-SteroidalDose-Response Relationship, DrugDrug Administration ScheduleFemaleFollow-Up StudiesHumansHyaluronic AcidInjections, Intra-ArticularKnee JointMagnetic Resonance ImagingMaleMiddle AgedOsteoarthritis, KneePain MeasurementRadiographyAnti-Inflammatory Agents, Non-SteroidalHyaluronic AcidViscosupplementsCartilage injuryHyaluronic acidIntra-articular injectionKnee osteoarthritisPlatelet-rich plasma

Identifiers

PMID30128934
PMCPMC6102156
OpenAlexW2884783263

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.