Evidence map›Paper›PMID 30128908›Full record

SynthesisHerz2020

Effect of ulinastatin on interleukins and pulmonary function in bypass patients: a meta-analysis of randomized controlled trials.

G He, Q Li, W Li, Y Ruan, X Xiong, X Song, F Zeng

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Herz, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

G HeDepartment of Respiratory Medicine, The First College of Clinical Medical Sciences, Yichang Central People's Hospital, China Three Gorges University, Yiling Road 183, 443000, Yichang, Hubei, China.ORCID http://orcid.org/0000-0003-2878-249X
Q LiDepartment of Cardiology, The First College of Clinical Medical Sciences, Institute of Cardiovascular Diseases, China Three Gorges University, Yichang, Hubei, China.
W LiDepartment of Respiratory Medicine, The First College of Clinical Medical Sciences, Yichang Central People's Hospital, China Three Gorges University, Yiling Road 183, 443000, Yichang, Hubei, China.
Y RuanDepartment of Respiratory Medicine, The First College of Clinical Medical Sciences, Yichang Central People's Hospital, China Three Gorges University, Yiling Road 183, 443000, Yichang, Hubei, China.
X XiongDepartment of Respiratory Medicine, The First College of Clinical Medical Sciences, Yichang Central People's Hospital, China Three Gorges University, Yiling Road 183, 443000, Yichang, Hubei, China.
X SongDepartment of Respiratory Medicine, The First College of Clinical Medical Sciences, Yichang Central People's Hospital, China Three Gorges University, Yiling Road 183, 443000, Yichang, Hubei, China.
F ZengDepartment of Respiratory Medicine, The First College of Clinical Medical Sciences, Yichang Central People's Hospital, China Three Gorges University, Yiling Road 183, 443000, Yichang, Hubei, China. yczengfanjun@163.com.
China Three Gorges University · CN

Funding

Health and Family Planning Commission Foundation of Hubei province, China WJ2015MB260Research Fund for Excellent Dissertation of China Three Gorges University 2018SSPY094
6 · The paper itself

Abstract

backgroundOur aim was to evaluate the effect of urinary trypsin inhibitors (UTI) on interleukin, tumor necrosis factor-α (TNF-α), and polymorphonuclear neutrophil elastase (PMNE) levels as well as on pulmonary function in patients undergoing cardiopulmonary bypass. MATERIALS AND

methodsWe searched the following databases for relevant studies: PubMed, Medline (Ovid SP), Cochrane Library, Wanfang Data, China Biology Medicine Database, Chinese Periodical Database, China Knowledge Resource Integrated Database, and Chinese Clinical Trial Registry. Two investigators independently collected the data and assessed the quality of each study. RevMan 5.3 was used for the meta-analysis.

resultsIn total, 15 randomized controlled trials (646 patients) met the inclusion criteria. There was a significant decrease in TNF-α, interleukin-6 (IL-6), IL-8, and PMNE levels at 6 h and 24 h after UTI treatment and an increase in IL-10 levels; additionally, there was a decrease in respiratory index and an improvement in the oxygenation index. Nevertheless, UTI treatment did not affect the length of intensive care unit stay, alveolar-arterial oxygen partial pressure difference, adverse lung events, or hospital mortality. Because of the high heterogeneity of the included trials, the results should be assessed carefully.

conclusionUTI treatment can suppress proinflammatory cytokine elevation and upregulate the release of anti-inflammatory mediators, thereby reducing pulmonary injury and improving pulmonary function after cardiopulmonary bypass.

Indexed as

Cardiopulmonary BypassGlycoproteinsInterleukinsLungTrypsin InhibitorsChinaHumansRandomized Controlled Trials as TopicGlycoproteinsInterleukinsTrypsin InhibitorsurinastatinCardiopulmonary bypassCytokinesPulmonary functionPulmonary injuryTrypsin inhibitor

Identifiers

PMID30128908
OpenAlexW2888597221

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.