Evidence map›Paper›PMID 30128850›Full record

ArticleEuropean journal of applied physiology2018

How many squat-stand manoeuvres to assess dynamic cerebral autoregulation?

S C Barnes, N Ball, V J Haunton, T G Robinson, R B Panerai

Abstract read
In one paragraph

Article in European journal of applied physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. A systematic review, meta-analysisJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Pooled it
  2. Article
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  6. Directional sensitivity of dynamic cerebral autoregulation during spontaneous fluctuations in arterial blood pressure at rest.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  7. Transfer function analysis of dynamic cerebral autoregulation: A CARNet white paper 2022 update.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

S C BarnesDepartment of Cardiovascular Sciences, University of Leicester, Room 210, Robert Kilpatrick Clinical Sciences Building, PO Box 65, Leicester, LE2 7LX, UK.
N BallDepartment of Cardiovascular Sciences, University of Leicester, Room 210, Robert Kilpatrick Clinical Sciences Building, PO Box 65, Leicester, LE2 7LX, UK.
V J HauntonDepartment of Cardiovascular Sciences, University of Leicester, Room 210, Robert Kilpatrick Clinical Sciences Building, PO Box 65, Leicester, LE2 7LX, UK. vjh12@le.ac.uk.
T G RobinsonDepartment of Cardiovascular Sciences, University of Leicester, Room 210, Robert Kilpatrick Clinical Sciences Building, PO Box 65, Leicester, LE2 7LX, UK.
R B PaneraiDepartment of Cardiovascular Sciences, University of Leicester, Room 210, Robert Kilpatrick Clinical Sciences Building, PO Box 65, Leicester, LE2 7LX, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSquat-stand manoeuvres (SSMs) have been used to induce blood pressure (BP) changes for the reliable assessment of dynamic cerebral autoregulation. However, they are physically demanding and thus multiple manoeuvres can be challenging for older subjects. This study aimed to determine the minimum number of SSMs required to obtain satisfactory coherence, thus minimising the subjects' workload.

method20 subjects performed SSMs at a frequency of 0.05 Hz. End-tidal CO

resultsAfter three SSMs, coherence (0.05 Hz) was 0.93 ± 0.05, and peaked at 0.95 ± 0.02 after 12 manoeuvres. ARI decreased consecutively with more manoeuvres. ARI was comparable across the two visits (p = 0.92), but coherence was significantly enhanced during the second visit (p < 0.01). The intra-subject coefficients of variation (CoV) for ARI remained comparable as the number of manoeuvres varied.

conclusionsThis analysis can aid those designing SSM protocols, especially where participants are unable to tolerate a standard 5-min protocol or when a shorter protocol is needed to accommodate additional tests. We emphasise that fewer manoeuvres should only be used in exceptional circumstances, and where possible a full set of manoeuvres should be performed. Furthermore, these results need replicating at 0.10 Hz to ensure their applicability to different protocols.

Indexed as

Blood Flow VelocityBlood PressureCerebrovascular CirculationElectrocardiographyFemaleHeart RateHomeostasisHumansMaleMuscle ContractionPostureUltrasonography, Doppler, TranscranialYoung AdultAutoregulation indexCerebral blood flowSquat–stand manoeuvresTranscranial Doppler ultrasoundTransfer function analysis

Identifiers

PMID30128850
PMCPMC6182316

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.