Evidence map›Paper›PMID 30128766›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2018

Post-traumatic stress disorder and incident fractures in the Danish population.

T Jiang, K Veres, D Körmendiné Farkas, T L Lash, H T Sørensen, J L Gradus

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Observational
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

T JiangDepartment of Epidemiology, Boston University, 715 Albany Street, Boston, MA, 02118, USA.
K VeresDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
D Körmendiné FarkasDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
T L LashDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
H T SørensenDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
J L GradusDepartment of Epidemiology, Boston University, 715 Albany Street, Boston, MA, 02118, USA. jgradus@bu.edu.
Aarhus University Hospital · DKBoston University · USNational Center for PTSD · US

Funding

Characterizing Trauma Outcomes: From Pre-trauma Risk to Post-trauma SequelaeR01MH110453 · NIMH · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GRADUS, JAIMIE L. · 2017 to 2020
$1.3M
Constructing a Danish Reaction to Severe Stress CohortR21MH094551 · NIMH · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GRADUS, JAIMIE L. · 2012 to 2013
$321k
National Institute of Mental Health 1R01MH110453-01A1National Institute of Mental Health 1R21MH094551-01A1NIMH NIH HHS R01 MH110453NIMH NIH HHS R21 MH094551
6 · The paper itself

Abstract

Psychological stress may be associated with increased risk of fractures. It is unknown whether post-traumatic stress disorder (PTSD), a marker of chronic severe psychological stress occurring in response to a traumatic event, influences fracture risk. In this nationwide cohort study, persons with PTSD had an increased risk of fractures compared to the general population.

introductionWe conducted a population-based national cohort study in Denmark to examine the association between PTSD and incident fractures.

methodsWe examined the incidence rate of overall and specific fractures among patients with clinician-diagnosed PTSD (n = 4114), compared with the incidence rate in the general population from 1995 to 2013, using Danish medical registry data. We further examined differences in associations by gender, age, psychiatric and somatic comorbidity, and follow-up time. We calculated absolute risks, standardized incidence ratios (SIRs), and 95% confidence intervals (95% CIs).

resultsRisk of any fracture among persons with PTSD was 24% (95% CI 20%, 28%) over the study period. The SIR for any fracture was 1.7 (95% CI 1.6, 1.9). We found little evidence of effect measure modification of the association between PTSD and fractures in our stratified analyses.

conclusionsOur findings suggest that PTSD is associated with increased fracture risk.

Indexed as

AdolescentAdultAgedComorbidityDenmarkFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedOsteoporotic FracturesRegistriesRisk AssessmentStress Disorders, Post-TraumaticYoung AdultFractureLongitudinalNationwidePost-traumatic stress disorderStress

Identifiers

PMID30128766
PMCPMC6193821
OpenAlexW2888095061

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.